Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides
Mathieu E, Bernard AS, Ching HY, Somogyi A, Medjoubi K, Fores JR, Bertrand HC, Vincent A, Trépout S, Guerquin-Kern JL, Scheitler A, Ivanovic-Burmazovic I, Seksik P, Delsuc N, Policar C (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 49
Pages Range: 2323-2330
Journal Issue: 7
DOI: 10.1039/c9dt04619d
Abstract
A superoxide dismutase mimic (Mn1) was functionalized with three positively charged-peptides: RRRRRRRRR (Mn1-R9), RRWWWRRWRR (Mn1-RW9) or Fx-r-Fx-K (Mn1-MPP). Characterization of the physico-chemical properties of the complexes show that they share similar binding affinity for Mn2+, apparent reduction potential and intrinsic superoxide dismutase activity. However, their accumulation in cells is different (Mn1-R9 < Mn1-MPP < Mn1-RW9 < Mn1), as well as their subcellular distribution. In addition, the three functionalized-complexes display a better anti-inflammatory activity than Mn1 when assayed at 10 μM. This improvement is due to a combination of an anti-inflammatory effect of the peptidyl moiety itself, and of the SOD mimic for Mn1-RW9 and Mn1-MPP. In contrast, the enhanced anti-inflammatory activity of Mn1-R9 is solely due to the SOD mimic.
Authors with CRIS profile
Andreas Scheitler
Lehrstuhl für Bioanorganische Chemie
Ivana Ivanovic-Burmazovic
Lehrstuhl für Bioanorganische Chemie
Involved external institutions
France (FR)How to cite
APA:
Mathieu, E., Bernard, A.S., Ching, H.Y., Somogyi, A., Medjoubi, K., Fores, J.R.,... Policar, C. (2020). Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides. Dalton Transactions, 49(7), 2323-2330. https://dx.doi.org/10.1039/c9dt04619d
MLA:
Mathieu, Emilie, et al. "Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides." Dalton Transactions 49.7 (2020): 2323-2330.
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