Combined antifungal therapy is superior to monotherapy in pulmonary scedosporiosis in cystic fibrosis
Schwarz C, Brandt C, Melichar V, Runge C, Heuer E, Sahly H, Schebek M, Koester H, Bouchara JP, Biedermann T, Meissner P, Grosse-Onnebrink J, Skopnik H, Hartl D, Sedlacek L, Tintelnot K (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 18
Pages Range: 227-232
Journal Issue: 2
DOI: 10.1016/j.jcf.2018.08.012
Abstract
Cystic fibrosis (CF) is characterised by chronic airway infection with bacteria and fungi. Infections caused by Scedosporium/Lomentospora species can occur and are difficult to treat. Moulds belonging to the genus Scedosporium/Lomentospora are detected most frequently in respiratory samples of patients with CF, next to Aspergillus spp. Our aim was to define pulmonary fungal infections due to Scedosporium/Lomentospora in CF and to study the antimycotic treatment. In this multicentre study (12 centres; duration January 2008 to December 2014) 31 patients with a lung infection caused by moulds of the genus Scedosporium/Lomentospora were included. 36 courses of antifungal treatment were documented. Scedosporium apiospermum sensu stricto accounted for 48.4% of cases. In 20/31 patients a therapeutic response under antimycotics (median duration 3.9 months) was achieved. Triple and double therapy was significantly more effective compared to monotherapy regarding FEV 1 , radiology, and symptoms. This data suggests that combined treatment is superior to monotherapy in patients with CF.
Involved external institutions
Klinikum Oldenburg
Germany (DE)
Labor Lademannbogen
Germany (DE)
Robert Koch-Institut (RKI)
Germany (DE)
Klinikum Kassel GmbH
Germany (DE)
Universitätsklinikum Ulm
Germany (DE)
Centre hospitalier universitaire (CHU) d'Angers
France (FR)
Charité - Universitätsmedizin Berlin
Germany (DE)
Klinikum Worms
Germany (DE)
HELIOS Kliniken
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Universitätsklinikum des Saarlandes (UKS)
Germany (DE)
Germany (DE)
Labor Lademannbogen
Germany (DE)
Robert Koch-Institut (RKI)
Germany (DE)
Klinikum Kassel GmbH
Germany (DE)
Universitätsklinikum Ulm
Germany (DE)
Centre hospitalier universitaire (CHU) d'Angers
France (FR)
Charité - Universitätsmedizin Berlin
Germany (DE)
Klinikum Worms
Germany (DE)
HELIOS Kliniken
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Universitätsklinikum des Saarlandes (UKS)
Germany (DE)
How to cite
APA:
Schwarz, C., Brandt, C., Melichar, V., Runge, C., Heuer, E., Sahly, H.,... Tintelnot, K. (2019). Combined antifungal therapy is superior to monotherapy in pulmonary scedosporiosis in cystic fibrosis. Journal of Cystic Fibrosis, 18(2), 227-232. https://dx.doi.org/10.1016/j.jcf.2018.08.012
MLA:
Schwarz, Carsten, et al. "Combined antifungal therapy is superior to monotherapy in pulmonary scedosporiosis in cystic fibrosis." Journal of Cystic Fibrosis 18.2 (2019): 227-232.
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