Prevalence of the apolipoprotein E ?4 allele in amyloid ? positive subjects across the spectrum of Alzheimer's disease

Mattsson N, Groot C, Jansen WJ, Landau SM, Villemagne VL, Engelborghs S, Mintun MM, Lleo A, Molinuevo JL, Jagust WJ, Frisoni GB, Ivanoiu A, Chetelat G, De Oliveira CR, Rodrigue KM, Kornhuber J, Wallin A, Klimkowicz-Mrowiec A, Kandimalla R, Popp J, Aalten PP, Aarsland D, Alcolea D, Almdahl IS, Baldeiras I, Van Buchem MA, Cavedo E, Chen K, Cohen AD, Foerster S, Fortea J, Frederiksen KS, Freund-Levi Y, Gill KD, Gkatzima O, Grimmer T, Hampel H, Herukka SK, Johannsen P, Van Laere K, De Leon MJ, Maier W, Marcusson J, Meulenbroek O, Mollergard HM, Morris JC, Mroczko B, Nordlund A, Prabhakar S, Peters O, Rami L, Rodriguez-Rodriguez E, Roe CM, Ruther E, Santana I, Schroder J, Seo SW, Soininen H, Spiru L, Stomrud E, Struyfs H, Teunissen CE, Verhey FRJ, Vos SJB, Van Doorn LJCVW, Waldemar G, Wallin AK, Wiltfang J, Vandenberghe R, Brooks DJ, Fladby T, Rowe CC, Drzezga A, Verbeek MM, Sarazin M, Wolk DA, Fleisher AS, Klunk WE, Na DL, Sanchez-Juan P, Lee DY, Nordberg A, Tsolaki M, Camus V, Rinne JO, Fagan AM, Zetterberg H, Blennow K, Rabinovici GD, Hansson O, Van Berckel BNM, Van Der Flier WM, Scheltens P, Visser PJ, Ossenkoppele R (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Book Volume: 14

Pages Range: 913-924

Journal Issue: 7

DOI: 10.1016/j.jalz.2018.02.009

Abstract

Apolipoprotein E (APOE) ?4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid ? (A?) pathology.We included 3451 A?+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE ?4 prevalence in relation to age, sex, education, and geographical location.The APOE ?4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in A?+ cognitively normal and A?+ mild cognitive impairment (P < .05) but not in A?+ AD dementia (P = .66). The prevalence was highest in Northern Europe but did not vary by sex or education.The APOE ?4 prevalence in AD was higher than that in previous studies, which did not require presence of A? pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location.

Authors with CRIS profile

Involved external institutions

Vrije Universiteit Amsterdam (VU) / University Amsterdam Netherlands (NL) Lausanne University Hospital / Centre hospitalier universitaire vaudois (CHUV) Switzerland (CH) Maastricht University Netherlands (NL) Stavanger University Hospital Norway (NO) Hospital de la Santa Creu i Sant Pau Spain (ES) Akershus University Hospital / Akershus universitetssykehus (Ahus) Norway (NO) Centro Hospitalar e Universitário de Coimbra (CHUC) Portugal (PT) University of California, Berkeley United States (USA) (US) Lund University / Lunds universitet Sweden (SE) University of Antwerp / Universiteit Antwerpen Belgium (BE) Austin Health Australia (AU) Avid Radiopharmaceuticals, Inc., United States (USA) (US) Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Spain (ES) Geneva University Hospitals / Hôpitaux universitaires de Genève (HUG) Switzerland (CH) UNICAEN Université de Caen Normandie France (FR) University of Texas at Dallas (UTD / UT Dallas) United States (USA) (US) University of Gothenburg / Göteborgs universitet Sweden (SE) Jagiellonian University / Uniwersytet Jagielloński (UJ) Poland (PL) Postgraduate Institute of Medical Education and Research India (IN) Georg-August-Universität Göttingen Germany (DE) Universität zu Köln Germany (DE) University of Pennsylvania United States (USA) (US) Banner Sun Health Research Institute United States (USA) (US) Sungkyunkwan University (SKKU) Korea, Republic of (KR) Instituto de Investigación Marqués de Valdecilla (IDIVAL) Spain (ES) Seoul National University (SNU) / 서울대학교 Korea, Republic of (KR) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) Aristotle University of Thessaloniki Greece (GR) François Rabelais University Tours France (FR) University of Turku / Turun yliopisto Finland (FI) Washington University in St. Louis United States (USA) (US) University College London (UCL) United Kingdom (GB) Leiden University Netherlands (NL) Istituto di ricovero e cura a carattere scientifico (IRCCS) Italy (IT) University of Pittsburgh United States (USA) (US) Technische Universität München (TUM) Germany (DE) University of Copenhagen Denmark (DK) Karolinska Institute Sweden (SE) University of Paris 6 - Pierre et Marie Curie / Université Paris VI Pierre et Marie Curie (UPMC) France (FR) University of Eastern Finland Finland (FI) Rigshospitalet Denmark (DK) Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven Belgium (BE) New York University (NYU) United States (USA) (US) Rheinische Friedrich-Wilhelms-Universität Bonn Germany (DE) Linköpings universitet / Linköping University Sweden (SE) Radboud University Nijmegen Netherlands (NL) University of Białystok Poland (PL) Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Germany (DE) Ruprecht-Karls-Universität Heidelberg Germany (DE) Carol Davila University of Medicine and Pharmacy / Universitatea de Medicină și Farmacie „Carol Davila” (UMF București) Romania (RO) Imperial College London / The Imperial College of Science, Technology and Medicine United Kingdom (GB) University of Paris 4 - Paris-Sorbonne / Université paris IV Paris-Sorbonne France (FR) University of California San Francisco (UCSF) United States (USA) (US)

How to cite

APA:

Mattsson, N., Groot, C., Jansen, W.J., Landau, S.M., Villemagne, V.L., Engelborghs, S.,... Ossenkoppele, R. (2018). Prevalence of the apolipoprotein E ?4 allele in amyloid ? positive subjects across the spectrum of Alzheimer's disease. Alzheimers & Dementia, 14(7), 913-924. https://doi.org/10.1016/j.jalz.2018.02.009

MLA:

Mattsson, Niklas, et al. "Prevalence of the apolipoprotein E ?4 allele in amyloid ? positive subjects across the spectrum of Alzheimer's disease." Alzheimers & Dementia 14.7 (2018): 913-924.

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