Clinical relevance of drug efflux pumps in the gut.
Misaka S, Müller F, Fromm M (2013)
Publication Status: Published
Publication Type: Journal article, Review article
Publication year: 2013
Journal
Book Volume: 13
Pages Range: 847-52
Journal Issue: 6
DOI: 10.1016/j.coph.2013.08.010
Abstract
Important export pumps expressed in the apical membrane of enterocytes are P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance protein 2 (MRP2). They are believed to be a crucial part of the bodies' defense mechanisms against potentially toxic, orally administered xenobiotics. In particular P-gp and BCRP also limit the bioavailability of drugs. Inhibition of these intestinal export pumps by concomitantly administered drugs leads to increased plasma concentrations, whereas induction can reduce absorption of the substrate drugs and decrease plasma concentrations. The role of polymorphisms in genes encoding for these transporters will also be discussed. Taken together this review will focus on the role of intestinal export pumps using selected examples from clinical studies in humans.
Authors with CRIS profile
Fabian Müller
Medizinische Fakultät
Martin Fromm
Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie
Involved external institutions
Japan (JP)How to cite
APA:
Misaka, S., Müller, F., & Fromm, M. (2013). Clinical relevance of drug efflux pumps in the gut. Current Opinion in Pharmacology, 13(6), 847-52. https://doi.org/10.1016/j.coph.2013.08.010
MLA:
Misaka, Shingen, Fabian Müller, and Martin Fromm. "Clinical relevance of drug efflux pumps in the gut." Current Opinion in Pharmacology 13.6 (2013): 847-52.
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