Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course

Cavagna L, Trallero-Araguas E, Meloni F, Cavazzana I, Rojas-Serrano J, Feist E, Zanframundo G, Morandi V, Meyer A, Pereira Da Silva JA, Matos Costa CJ, Molberg O, Andersson H, Codullo V, Mosca M, Barsotti S, Neri R, Scire C, Govoni M, Furini F, Javier Lopez-Longo F, Martinez-Barrio J, Schneider U, Lorenz HM, Doria A, Ghirardello A, Ortego-Centeno N, Confalonieri M, Tomietto P, Pipitone N, Rodriguez Cambron AB, Blazquez Canamero MA, Voll RE, Wendel S, Scarpato S, Maurier F, Limonta M, Colombelli P, Giannini M, Geny B, Arrigoni E, Bravi E, Migliorini P, Mathieu A, Piga M, Drott U, Delbrueck C, Bauhammer J, Cagnotto G, Vancheri C, Sambataro G, De Langhe E, Sainaghi PP, Monti C, Berzolari FG, Romano M, Bonella F, Specker C, Schwarting A, Villa Blanco I, Selmi C, Ceribelli A, Nuno L, Mera-Varela A, Perez Gomez N, Fusaro E, Parisi S, Sinigaglia L, Del Papa N, Benucci M, Cimmino MA, Riccieri V, Conti F, Sebastiani GD, Iuliano A, Emmi G, Cammelli D, Sebastiani M, Manfredi A, Bachiller-Corral J, Sifuentes Giraldo WA, Paolazzi G, Saketkoo LA, Giorgi R, Salaffi F, Cifrian J, Caporali R, Locatelli F, Marchioni E, Pesci A, Dei G, Pozzi MR, Claudia L, Distler J, Knitza J, Schett G, Iannone F, Fornaro M, Franceschini F, Quartuccio L, Gerli R, Bartoloni E, Randone SB, Zampogna G, Gonzalez Perez M, Mejia M, Vicente E, Triantafyllias K, Lopez-Mejias R, Matucci-Cerinic M, Selva-O'Callaghan A, Castaneda S, Montecucco C, Angel Gonzalez-Gay M (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Book Volume: 8

Journal Issue: 11

DOI: 10.3390/jcm8112013

Abstract

Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group's cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The "ex-novo" occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies' positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition.

Authors with CRIS profile

Involved external institutions

Azienda Ospedaliero-Universitaria Pisana Italy (IT) Oslo University Hospital / Oslo Universitetssykehus Rikshospitalet Norway (NO) Hôpital Cochin France (FR) ASST Papa Giovanni XXIII Italy (IT) Hôpitaux universitaires de Strasbourg (HUS) / University Hospital Strasbourg France (FR) Università degli Studi di Pavia Italy (IT) Centro Hospitalar e Universitário de Coimbra (CHUC) Portugal (PT) Hospital Universitario Severo Ochoa Spain (ES) Albert-Ludwigs-Universität Freiburg Germany (DE) Università Politecnica delle Marche (UNIVPM) / Marche Polytechnic University Italy (IT) Louisiana State University United States (USA) (US) Goethe-Universität Frankfurt am Main Germany (DE) Azienda Ospedaliero Universitaria "Policlinico - Vittorio Emanuele" Italy (IT) Charité - Universitätsmedizin Berlin Germany (DE) University of Padua / Universita degli Studi di Padova Italy (IT) Hôpital Belle-Isle France (FR) Hospital Universitario Ramón y Cajal Spain (ES) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) Careggi University Hospital / Azienda Ospedaliero Universitaria Careggi Italy (IT) Ospedale Niguarda Ca' Granda / ASST Grande Ospedale Metropolitano Niguarda Italy (IT) Presidio ospedaliero "Mauro Scarlato" Italy (IT) Università degli Studi di Modena e Reggio Emilia (UNIMORE) Italy (IT) University of Milano-Bicocca / Università degli Studi di Milano-Bicocca, UNIMIB Italy (IT) Università degli Studi di Ferrara Italy (IT) Hospital General Universitario Gregorio Marañón Spain (ES) Azienda Sanitaria Locale CN2 (ASL. Cuneo 2) Italy (IT) Universität Duisburg-Essen (UDE) Germany (DE) Ospedale Santa Chiara Italy (IT) Università degli Studi di Trieste Italy (IT) L'Ospedale Mauriziano di Torino Italy (IT) Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO Italy (IT) Universidade de Santiago Compostela (USC) Spain (ES) University of Bari Aldo Moro / Università degli Studi di Bari Aldo Moro Italy (IT) Instituto Nacional de Enfermedades Respiratorias Mexico (MX) Universidad de Cantabria (UC) Spain (ES) Ospedale Santa Maria della Misericordia di Udine Italy (IT) Istituto Clinico Humanitas Italy (IT) University of Genova / Università degli Studi di Genova Italy (IT) Università degli Studi di Brescia Italy (IT) Hospital Universitario La Paz Spain (ES) Università degli studi "La Sapienza" Italy (IT) Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona Spain (ES) Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino Italy (IT) Università degli Studi di Perugia Italy (IT) Skåne University Hospital / Skånes universitetssjukhus Sweden (SE) Ospedale Guglielmo da Saliceto Italy (IT) Krankenhaus Bruneck / Ospedale di Brunico Italy (IT) Fondazione "Istituto Neurologico Nazionale Casimiro Mondino" Italy (IT) Hospital Universitario De La Princesa Spain (ES) Université de Strasbourg (UDS) France (FR) Azienda ospedaliera San Camillo-Forlanini Italy (IT) Ospedale San Giovanni di Dio Italy (IT) ACURA Kliniken Germany (DE) Sierrallana Hospital Spain (ES) Policlinico San Matteo Pavia Fondazione IRCCS Italy (IT) University of Eastern Piedmont / Università degli Studi del Piemonte Orientale "Amedeo Avogadro" Italy (IT) Università degli studi di Milano Italy (IT) Universitätsklinikum Leipzig Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) Germany (DE) Ruprecht-Karls-Universität Heidelberg Germany (DE) Hospital Universitario San Cecilio Spain (ES) Ospedale "Treviglio-Caravaggio" di Treviglio Italy (IT)

How to cite

APA:

Cavagna, L., Trallero-Araguas, E., Meloni, F., Cavazzana, I., Rojas-Serrano, J., Feist, E.,... Angel Gonzalez-Gay, M. (2019). Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course. Journal of Clinical Medicine, 8(11). https://doi.org/10.3390/jcm8112013

MLA:

Cavagna, Lorenzo, et al. "Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course." Journal of Clinical Medicine 8.11 (2019).

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