Carborane-Based Analogues of 5-Lipoxygenase Inhibitors Co-inhibit Heat Shock Protein 90 in HCT116 Cells

Kuhnert R, Sarosi MB, George S, Loennecke P, Hofmann B, Steinhilber D, Steinmann S, Schneider-Stock R, Murganic B, Mijatovic S, Maksimovic-Ivanic D, Hey-Hawkins E (2019)

Publication Type: Journal article

Publication year: 2019

Journal

ChemMedChem Wiley

Book Volume: 14

Pages Range: 255-261

Journal Issue: 2

DOI: 10.1002/cmdc.201800651

Abstract

5-Lipoxygenase converts arachidonic acid into leukotrienes, which are involved in inflammation and angiogenesis. The introduction of carboranes can improve the pharmacokinetic behavior of metabolically less stable pharmaceutics. Herein we report the syntheses of several carborane-based inhibitors of the 5-lipoxygenase pathway. The isosteric replacement of phenyl rings by carboranes leads to improved cytotoxicity toward several melanoma and colon cancer cell lines. For the colon cancer cell line HCT116, the co-inhibition of heat shock protein 90 was observed.

Authors with CRIS profile

Sara Steinmann Institute of Pathology Regine Schneider-Stock Professur für Experimentelle Tumorpathologie

Involved external institutions

Universität Leipzig DE Germany (DE) Goethe-Universität Frankfurt am Main DE Germany (DE) University of Belgrade / Универзитет у Београду RS Serbia (RS)

How to cite

APA:

Kuhnert, R., Sarosi, M.-B., George, S., Loennecke, P., Hofmann, B., Steinhilber, D.,... Hey-Hawkins, E. (2019). Carborane-Based Analogues of 5-Lipoxygenase Inhibitors Co-inhibit Heat Shock Protein 90 in HCT116 Cells. ChemMedChem, 14(2), 255-261. https://doi.org/10.1002/cmdc.201800651

MLA:

Kuhnert, Robert, et al. "Carborane-Based Analogues of 5-Lipoxygenase Inhibitors Co-inhibit Heat Shock Protein 90 in HCT116 Cells." ChemMedChem 14.2 (2019): 255-261.

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