Enhancing biological activity of bioactive glass scaffolds by inorganic ion delivery for bone tissue engineering

Mouriño V, Vidotto R, Cattalini JP, Boccaccini AR (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Current Opinion in Biomedical Engineering Elsevier

Book Volume: 10

Pages Range: 23-34

DOI: 10.1016/j.cobme.2019.02.002

Abstract

This review covers recent research on therapeutic inorganic ions' (TIIs) ‘in situ’ delivery for bone repair and highlights some of the challenges involved, especially related to TII delivery in a controlled and sustained manner from bone tissue engineering (BTE) scaffolds. Strategies for the delivery of relevant biologically active ions with potential angiogenic and osteogenic effects in BTE approaches reported during the last five years are discussed, and the description of delivery techniques to meet bone regeneration requirements is presented. From early approaches using conventional bioceramics, the field has grown tremendously, driven in part by innovations in the biomaterials field, particularly bioactive glasses loaded with and capable to deliver TIIs. Modern advances in drug delivery applied to regenerative medicine focus on the rational design of scaffolds tailored for specific cargo and engineered to exert distinct biological functions. However, even though there is no release system universally suited to different TIIs, specific features and problems of one design or material type can shed light on how to approach TII release in BTE applications generally. Successful strategies to overcome current challenges will have broad application in bone regeneration with great promise for future clinical therapies.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Universidad de Buenos Aires (UBA) / University of Buenos Aires AR Argentina (AR)

How to cite

APA:

Mouriño, V., Vidotto, R., Cattalini, J.P., & Boccaccini, A.R. (2019). Enhancing biological activity of bioactive glass scaffolds by inorganic ion delivery for bone tissue engineering. Current Opinion in Biomedical Engineering, 10, 23-34. https://doi.org/10.1016/j.cobme.2019.02.002

MLA:

Mouriño, V., et al. "Enhancing biological activity of bioactive glass scaffolds by inorganic ion delivery for bone tissue engineering." Current Opinion in Biomedical Engineering 10 (2019): 23-34.

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