Alteration of Physicochemical Properties for Antibody-Drug Conjugates and Their Impact on Stability
Bücheler J, Winzer M, Weber C, Gieseler H (2019)
Publication Type: Journal article, Review article
Publication year: 2019
Journal
DOI: 10.1016/j.xphs.2019.08.006
Abstract
Antibody conjugates, in particular antibody-drug conjugates (ADCs), are a fast-growing area in research and in the pharmaceutical industry. The covalent attachment of an antibody to a chemical moiety can be an effective measure for drug targeting or can also positively impact pharmacokinetics of small molecular compounds by serum half-life extension. Stability, physicochemical properties, and degradation pathways of biotherapeutics or small molecule therapeutics are often not totally known and understood. However, ADCs represent a hybrid of small molecular and macromolecular components, and their properties are still not fully understood and described. This review discusses the alteration of the physicochemical properties of antibodies upon conjugation of chemical moieties to its surface and the resulting impact on ADC stability.
Authors with CRIS profile
Jakob Bücheler
Naturwissenschaftliche Fakultät
Henning Gieseler
Lehrstuhl für Pharmazeutische Technologie und Biopharmazie
Involved external institutions
Germany (DE)How to cite
APA:
Bücheler, J., Winzer, M., Weber, C., & Gieseler, H. (2019). Alteration of Physicochemical Properties for Antibody-Drug Conjugates and Their Impact on Stability. Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.xphs.2019.08.006
MLA:
Bücheler, Jakob, et al. "Alteration of Physicochemical Properties for Antibody-Drug Conjugates and Their Impact on Stability." Journal of Pharmaceutical Sciences (2019).
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