Induction of necrosis in human macrophage cell lines by corynebacterium diphtheriae and corynebacterium ulcerans strains isolated from fatal cases of systemic infections

Weerasekera D, Hahn J, Herrmann M, Burkovski A (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Book Volume: 20

Article Number: 4109

Journal Issue: 17

DOI: 10.3390/ijms20174109

Abstract

When infecting a human host, Corynebacterium diphtheriae and Corynebacterium ulcerans are able to impair macrophage maturation and induce cell death. However, the underlying molecular mechanisms are not well understood. As a framework for this project, a combination of fluorescence microscopy, cytotoxicity assays, live cell imaging, and fluorescence-activated cell sorting was applied to understand the pathogenicity of two Corynebacterium strains isolated from fatal cases of systemic infections. The results showed a clear cytotoxic effect of the bacteria. The observed survival of the pathogens in macrophages and, subsequent, necrotic lysis of cells may be mechanisms explaining dissemination of C. diphtheriae and C. ulcerans to distant organs in the body.

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How to cite

APA:

Weerasekera, D., Hahn, J., Herrmann, M., & Burkovski, A. (2019). Induction of necrosis in human macrophage cell lines by corynebacterium diphtheriae and corynebacterium ulcerans strains isolated from fatal cases of systemic infections. International Journal of Molecular Sciences, 20(17). https://doi.org/10.3390/ijms20174109

MLA:

Weerasekera, Dulanthi, et al. "Induction of necrosis in human macrophage cell lines by corynebacterium diphtheriae and corynebacterium ulcerans strains isolated from fatal cases of systemic infections." International Journal of Molecular Sciences 20.17 (2019).

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