Curatopes Melanoma: A Database of Predicted T-cell Epitopes from Overly Expressed Proteins in Metastatic Cutaneous Melanoma.

Lischer C, Eberhardt M, Jaitly T, Schinzel C, Schaft N, Dörrie J, Schuler G, Vera González J (2019)


Publication Type: Journal article

Publication year: 2019

Journal

Book Volume: 79

Pages Range: 5452-5456

Journal Issue: 20

DOI: 10.1158/0008-5472.CAN-19-0296

Abstract

Therapeutic anticancer vaccination has been adapted as an immunotherapy in several solid tumors. However, the selection of promising candidates from the total quantity of possible epitopes poses a challenge to clinicians and bioinformaticians alike, and very few epitopes have been tested in experimental or clinical settings to validate their efficacy. Here, we present a comprehensive database of predicted nonmutated peptide epitopes derived from genes that are overly expressed in a group of 32 melanoma biopsies compared with healthy tissues and that were filtered against expression in a curated list of survival-critical tissues. We hypothesize that these "self-tolerant" epitopes have two desirable properties: they do not depend on mutations, being immediately applicable to a large patient collective, and they potentially cause fewer autoimmune reactions. To support epitope selection, we provide an aggregated score of expected therapeutic efficiency as a shortlist mechanism. The database has applications in facilitating epitope selection and trial design and is freely accessible at https://www.curatopes.com. SIGNIFICANCE: A database is presented that predicts and scores antitumor T-cell epitopes, with a focus on tolerability and avoidance of severe autoimmunity, offering a supplementary epitope set for further investigation in immunotherapy.

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How to cite

APA:

Lischer, C., Eberhardt, M., Jaitly, T., Schinzel, C., Schaft, N., Dörrie, J.,... Vera González, J. (2019). Curatopes Melanoma: A Database of Predicted T-cell Epitopes from Overly Expressed Proteins in Metastatic Cutaneous Melanoma. Cancer Research, 79(20), 5452-5456. https://doi.org/10.1158/0008-5472.CAN-19-0296

MLA:

Lischer, Christopher, et al. "Curatopes Melanoma: A Database of Predicted T-cell Epitopes from Overly Expressed Proteins in Metastatic Cutaneous Melanoma." Cancer Research 79.20 (2019): 5452-5456.

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