Artesunate derivative TF27 inhibits replication and pathogenesis of an oncogenic avian alphaherpesvirus
Bertzbach LD, Conradie AM, Hahn F, Wild M, Marschall M, Kaufer BB (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 171
Article Number: 104606
DOI: 10.1016/j.antiviral.2019.104606
Abstract
Nucleoside analogues have been the cornerstone of clinical treatment of herpesvirus infections since the 1970s. However, severe side effects and emergence of drug resistant viruses raise the need for alternative treatment options. We recently investigated the broad and strong antiherpesviral activity of the optimized artesunate derivative TF27 in vitro. TF27 efficiently inhibited replication of the highly oncogenic Marek's disease virus (MDV), a virus that infects chickens, causes deadly lymphomas and threatens poultry populations worldwide. In this study, we used this natural virus-host model for herpesvirus-induced cancer by infecting chickens with MDV, and evaluated the protective efficacy of TF27 and the nucleoside analogue valganciclovir (VGCV) on virus replication and tumorigenesis. We could demonstrate that both drugs reduced viral load in the blood and prevented tumor development in a large portion of the animals. Antiviral treatment also had a positive impact on body weight gain, while no negative compound-associated side effects were observed. This research provides the first evidence that the artesunate derivative TF27 and VGCV can be used in avian species and that they inhibit MDV replication and tumorigenesis. In addition, our study paves the way for promising approaches in future antiherpesviral drug development.
Authors with CRIS profile
Friedrich Hahn
Professur für Virologie
Markus Wild
Institute of Clinical and Molecular Virology
Manfred Marschall
Lehrstuhl für Klinische und Molekulare Virologie
Involved external institutions
Germany (DE)How to cite
APA:
Bertzbach, L.D., Conradie, A.M., Hahn, F., Wild, M., Marschall, M., & Kaufer, B.B. (2019). Artesunate derivative TF27 inhibits replication and pathogenesis of an oncogenic avian alphaherpesvirus. Antiviral Research, 171. https://dx.doi.org/10.1016/j.antiviral.2019.104606
MLA:
Bertzbach, Luca D., et al. "Artesunate derivative TF27 inhibits replication and pathogenesis of an oncogenic avian alphaherpesvirus." Antiviral Research 171 (2019).
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