Curcumin-Containing Orthopedic Implant Coatings Deposited on Poly-Ether-Ether-Ketone/Bioactive Glass/Hexagonal Boron Nitride Layers by Electrophoretic Deposition
Virk R, Ur Rehman MA, Munawar M, Schubert DW, Goldmann W, Dusza J, Boccaccini AR (2019)
Publication Language: English
Publication Type: Journal article, Review article
Publication year: 2019
Journal
URI: https://www.mdpi.com/2079-6412/9/9/572
DOI: 10.3390/coatings9090572
Abstract
Electrophoretic deposition (EPD) was used to produce
a multilayer coatings system based on chitosan/curcumin coatings on
poly-ether-ether-ketone (PEEK)/bioactive glass (BG)/hexagonal boron
nitride (h-BN) layers (previously deposited by EPD on 316L stainless
steel) to yield bioactive and antibacterial coatings intended for
orthopedic implants. Initially, PEEK/BG/h-BN coatings developed on 316L
stainless steel (SS) substrates were analyzed for wear studies. Then,
the EPD of chitosan/curcumin was optimized on 316L SS for suspension
stability, thickness, and homogeneity of the coatings. Subsequently, the
optimized EPD parameters were applied to produce chitosan/curcumin
coatings on the PEEK/BG/h-BN layers. The multilayered coatings produced
by EPD were characterized in terms of composition, microstructure, drug
release kinetics, antibacterial activity, and in vitro bioactivity.
Scanning electron microscopy (SEM) and Fourier transform infrared
spectroscopy (FTIR) confirmed the deposition of chitosan/curcumin on the
multilayer coating system. The release of curcumin upon immersion of
multilayer coatings in phosphate-buffered saline (PBS) was confirmed by
ultraviolet/visible (UV/VIS) spectroscopic analysis. The antibacterial
effect of chitosan/curcumin as the top coating was determined by
turbidity tests (optical density measurements). Moreover, the multilayer
coating system formed an apatite-like layer upon immersion in simulated
body fluid (SBF), which is similar in composition to the hydroxyapatite
component of bone, confirming the possibility of achieving close
bonding between bone and the coating surface.
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How to cite
APA:
Virk, R., Ur Rehman, M.A., Munawar, M., Schubert, D.W., Goldmann, W., Dusza, J., & Boccaccini, A.R. (2019). Curcumin-Containing Orthopedic Implant Coatings Deposited on Poly-Ether-Ether-Ketone/Bioactive Glass/Hexagonal Boron Nitride Layers by Electrophoretic Deposition. Coatings. https://doi.org/10.3390/coatings9090572
MLA:
Virk, Ranjot, et al. "Curcumin-Containing Orthopedic Implant Coatings Deposited on Poly-Ether-Ether-Ketone/Bioactive Glass/Hexagonal Boron Nitride Layers by Electrophoretic Deposition." Coatings (2019).
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