BMP6-induced modulation of the tumor micro-milieu

Stieglitz D, Lamm S, Braig S, Feuerer L, Kuphal S, Dietrich P, Arndt S, Echtenacher B, Hellerbrand C, Karrer S, Boßerhoff AK (2019)

Publication Type: Journal article

Publication year: 2019


Book Volume: 38

Pages Range: 609-621

Journal Issue: 5

DOI: 10.1038/s41388-018-0475-x


Melanoma is the deadliest form of skin cancer with rising incidence, creating a significant health problem. We discovered increased expression of bone morphogenetic protein 6 (BMP6) in melanoma cells and tissues, and observed that BMP6 deficiency caused significantly delayed tumor onset and decelerated tumor progression in a melanoma mouse model. Moreover, we determined that BMP6 inhibits dermal mast cell recruitment and found that mast cell-derived mediators significantly reduced melanoma growth in vitro. In line with this, mast cell deficiency accelerated tumor onset and progression in a melanoma mouse model. Analysis of human melanoma tissues revealed a strong negative correlation between melanoma proliferation and mast cell infiltration. This study elucidates a novel role of BMP6-induced modulation of the tumor microenvironment.

Authors with CRIS profile

Additional Organisation(s)

Involved external institutions

How to cite


Stieglitz, D., Lamm, S., Braig, S., Feuerer, L., Kuphal, S., Dietrich, P.,... Boßerhoff, A.K. (2019). BMP6-induced modulation of the tumor micro-milieu. Oncogene, 38(5), 609-621.


Stieglitz, David, et al. "BMP6-induced modulation of the tumor micro-milieu." Oncogene 38.5 (2019): 609-621.

BibTeX: Download