Neural correlates of olfactory and visual memory performance in 3D-simulated mazes after intranasal insulin application

Bruenner YF, Rodriguez-Raecke R, Mutic S, Benedict C, Freiherr J (2016)

Publication Status: Published

Publication Type: Journal article

Publication year: 2016

Journal

Neurobiology of Learning and Memory Elsevier

Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE

Book Volume: 134

Pages Range: 256-263

DOI: 10.1016/j.nlm.2016.07.027

Abstract

This fMRI study intended to establish 3D-simulated mazes with olfactory and visual cues and examine the effect of intranasally applied insulin on memory performance in healthy subjects. The effect of insulin on hippocampus-dependent brain activation was explored using a double-blind and placebo-controlled design. Following intranasal administration of either insulin (40 ID) or placebo, 16 male subjects participated in two experimental MRI sessions with olfactory and visual mazes. Each maze included two separate runs. The first was an encoding maze during which subjects learned eight olfactory or eight visual cues at different target locations. The second was a recall maze during which subjects were asked to remember the target cues at spatial locations. For eleven included subjects in the fMRI analysis we were able to validate brain activation for odor perception and visuospatial tasks. However, we did not observe an enhancement of declarative memory performance in our behavioral data or hippocampal activity in response to insulin application in the fMRI analysis. It is therefore possible that intranasal insulin application is sensitive to the methodological variations e.g. timing of task execution and dose of application. Findings from this study suggest that our method of 3D-simulated mazes is feasible for studying neural correlates of olfactory and visual memory performance. (C) 2016 Elsevier Inc. All rights reserved.

Authors with CRIS profile

Jessica Freiherr

Involved external institutions

Universitätsklinikum Aachen (UKA) DE Germany (DE) Uppsala University SE Sweden (SE) Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen DE Germany (DE)

How to cite

APA:

Bruenner, Y.F., Rodriguez-Raecke, R., Mutic, S., Benedict, C., & Freiherr, J. (2016). Neural correlates of olfactory and visual memory performance in 3D-simulated mazes after intranasal insulin application. Neurobiology of Learning and Memory, 134, 256-263. https://doi.org/10.1016/j.nlm.2016.07.027

MLA:

Bruenner, Yvonne F., et al. "Neural correlates of olfactory and visual memory performance in 3D-simulated mazes after intranasal insulin application." Neurobiology of Learning and Memory 134 (2016): 256-263.

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