Budday S, Holzapfel GA, Steinmann P, Kuhl E (2019)
Publication Type: Journal article, Original article
Publication year: 2019
Publisher: WILEY-VCH Verlag GmbH & Co. KGaA
City/Town: Weinheim
Book Volume: accepted
Conference Proceedings Title: accepted
Event location: Wien
While long underestimated, more and more evidence confirms that mechanics play a critical role for brain function and dysfunction. Therefore, computational simulations based on the field equations of nonlinear continuum mechanics can provide important insights into the underlying mechanisms of brain injury and disease. Realistic numerical predictions, however, require models capable of capturing the complex and unique mechanical behavior of this ultrasoft, highly heterogeneous and adaptive tissue. In recent years, contradictory experimental results have retarded progress in this field. Here, we summarize the key characteristics of brain tissue behavior on different length and time scales and propose application-specific modeling approaches, which are as complex as necessary but as simple as possible. The presented considerations will, on the one hand, facilitate well-designed future experiments and, on the other hand, help to choose the appropriate constitutive law for a specific application.
APA:
Budday, S., Holzapfel, G.A., Steinmann, P., & Kuhl, E. (2019). Challenges and perspectives in brain tissue testing and modeling. Proceedings in Applied Mathematics and Mechanics, accepted. https://doi.org/10.1002/pamm.201900269
MLA:
Budday, Silvia, et al. "Challenges and perspectives in brain tissue testing and modeling." Proceedings in Applied Mathematics and Mechanics accepted (2019).
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