The roles of astrocyte in the brain pathologies following ischemic stroke

Sun L, Zhang Y, Liu E, Ma Q, Anatol M, Han H, Yan J (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Brain Injury Informa Healthcare

Book Volume: 33

Pages Range: 712-716

Journal Issue: 6

DOI: 10.1080/02699052.2018.1531311

Abstract

Aim: In this work, we systematically explored the physiological functions of astrocytes and their roles following ischemic stroke, additionally, the potential therapy strategy targeting the astrocytes was also discussed. Methods: This work searched the PubMed database (including MEDLINE) until 14 Feb 2018, and furthermore, the studies were identified through cross-referencing and by consulting the experts in this field. Results: This study indicated that the astrocytes can not only play harmful roles following ischemic stroke through release of inflammatory factors and formation of glial scar but also have protective effects through quenching glutamate excitotoxicity and maintaining the clearance function of glymphatic system in brain. Conclusion: Owing to their important roles in physiological functions of brain and in the pathological conditions following ischemic stroke, the astrocytes might be a potential but promising therapeutic target for treating the ischemic stroke in the future.

Involved external institutions

Peking University (PKU) / 北京大学 CN China (CN) Loma Linda University (LLU) US United States (USA) (US)

How to cite

APA:

Sun, L., Zhang, Y., Liu, E., Ma, Q., Anatol, M., Han, H., & Yan, J. (2019). The roles of astrocyte in the brain pathologies following ischemic stroke. Brain Injury, 33(6), 712-716. https://dx.doi.org/10.1080/02699052.2018.1531311

MLA:

Sun, Linlin, et al. "The roles of astrocyte in the brain pathologies following ischemic stroke." Brain Injury 33.6 (2019): 712-716.

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