C-reactive protein levels in dried blood spots are associated with frontal resting-state beta-asymmetry
Becker L, Rohleder N (2019)
Publication Language: English
Publication Type: Conference contribution, Conference Contribution
Publication year: 2019
Event location: Berlin
Abstract
Frontal resting-state asymmetry (FRSA) has been associated with emotional and motivational processes. Furthermore, it has been shown that FRSA is related with mental illness (e.g., with depression, burnout, and anxiety disorders). These have also been associated with increased inflammatory markers (e. g., with C-reactive protein (CRP) levels). In this study, we investigated whether CRP levels are associated with FRSA as well. Forty-eight healthy adults participated (mean age = 23.3 +/-3.5 years, 25 female, BMI = 23.4 +/-3.1 kg/m2). Resting-state electroencephalography (EEG) activity was assessed during a two-minute period with eyes closed under the F3 and F4 electrodes. A resting-state asymmetry-index (AI) was calculated as AI = ln(F4/F3), separately for the α- (8-12 Hz) and β- (13-30 Hz) frequency bands. CRP was assessed by means of dried blood spots. Partial correlations, corrected for age, sex, and BMI were computed. Participants with higher CRP levels showed smaller AIs in the β-frequency range (r(43) = -.31, p =.041) and, therefore, higher β-activity over the left hemisphere. For the α-frequency range, a trend in the same direction was found (r(43) = -.25, p =.092). Our findings are in line with previous studies which reported higher left frontal activity in mentally ill people. Furthermore, our results support the assumption that resting state brain activity is related with inflammatory regulation.
Authors with CRIS profile
Linda Becker
Lehrstuhl für Gesundheitspsychologie
Nicolas Rohleder
Lehrstuhl für Gesundheitspsychologie
How to cite
APA:
Becker, L., & Rohleder, N. (2019). C-reactive protein levels in dried blood spots are associated with frontal resting-state beta-asymmetry. In Proceedings of the 26th Annual PNIRS and GEBIN Scientific Meeting. Berlin, DE.
MLA:
Becker, Linda, and Nicolas Rohleder. "C-reactive protein levels in dried blood spots are associated with frontal resting-state beta-asymmetry." Proceedings of the 26th Annual PNIRS and GEBIN Scientific Meeting, Berlin 2019.
BibTeX: Download