Agaimy A (2019)
Publication Type: Journal article, Review article
Publication year: 2019
DOI: 10.1007/s00292-019-0623-2
Soft tissue neoplasms with myxoid features are collectively not uncommon. Their often complex differential diagnosis makes them significantly over-represented among consultation cases. This applies not only to sarcomas but in particular to benign lesions as well. Generally, myxoid soft tissue lesions are divided into two major groups: (1) myxoid lesions by definition (which can however rarely be non-myxoid) and (2) rare myxoid variants of otherwise non-myxoid entities. Four major diagnostic challenges are responsible for the complexity of myxoid soft tissue neoplasms: (1) Diagnosis of malignancy in many cases is not based on conventional malignancy criteria but is defined by the entity itself, making under-diagnosis of malignancy likely in entities such as low-grade fibromyxoid sarcoma. (2) On the other hand, harmless myxoid lesions with features of high proliferation, e.g. nodular and proliferative fasciitis, tend to be over-diagnosed as malignant by the unworried. (3) The necessity to assess not only cellular morphology/differentiation, but also the stromal, vascular and architectural characteristics adds to the complexity of the differential diagnostic algorithm. (4) Last but not least, recognition of unexpected myxoid variants of non-myxoid entities is basically impossible if focal conventional areas are absent, underlining the need for high suspicion index and sufficient sampling. This review illuminates the various aspects related to the differential diagnostic workup of these challenging entities.
APA:
Agaimy, A. (2019). Myxoide Weichgewebstumoren: Ein Algorithmus zur Differenzialdiagnose. Pathologe. https://doi.org/10.1007/s00292-019-0623-2
MLA:
Agaimy, Abbas. "Myxoide Weichgewebstumoren: Ein Algorithmus zur Differenzialdiagnose." Pathologe (2019).
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