The course of cancer-related insomnia: don't expect it to disappear after cancer treatment
Schieber K, Niecke A, Geiser F, Erim Y, Bergelt C, Büttner-Teleaga A, Maatouk I, Stein B, Teufel M, Wickert M, Wuensch A, Weis J (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 58
Pages Range: 107-113
DOI: 10.1016/j.sleep.2019.02.018
Abstract
Objective: The study aimed to examine the 12-month course of cancer-related insomnia (CRI) and to identify possible predictors for the prevalence and persistence of CRI. Methods: This longitudinal multicenter study included N = 405 patients with cancer (56% females, mean age: 58.6 years). CRI was measured by the Insomnia Severity Index (ISI). Socio-demographic and clinical data, as well as psychological parameters (Distress Thermometer, PHQ-9, GAD-7, and EORTC-Fatigue), were assessed at baseline (T1) and 12 months later (T2). Results: In our sample, a high prevalence of relevant insomnia symptoms (49.4%, ISI > 7) was found, while a clinical insomnia diagnosis was verified in 12.8% (ISI > 14). When insomnia was present at T1, this problem was persistent after one year in 64%. At T2, however, significantly more women suffered from insomnia symptoms (53.3% women vs. 39.3% men; p = 0.003). Insomnia was associated with many clinical and psychological parameters, especially with fatigue (r = 0.5). Multiple regression analysis revealed that, in women, only insomnia at T1 was a significant predictor for insomnia at T2 (R2 = 0.40; F(5) = 12.5; p < 0.001), whereas in men insomnia, depressive symptoms and the use of psychotropic drugs at T1 predicted the extent of insomnia at T2 (R2 = 0.28; F(7) = 9.5; p < 0.001). In all participants, levels of distress, depression, and anxiety decreased from T1 to T2 (p's < 0.016). Conclusion: Insomnia is a common disorder in cancer patients. Although medical and psychological parameters improved during the 12-month course of cancer treatment, our results show that insomnia is highly persistent, especially in women. This indicates that adequate support for those affected is needed. Clinical Trial Registration Number: DRKS00004860.
Authors with CRIS profile
Katharina Schieber
Department of Psychosomatic Medicine and Psychotherapy
Yesim Erim
Professur für Psychosomatik und Psychotherapie
Involved external institutions
Paracelsus Medizinische Privatuniversität, Nürnberg
Germany (DE)
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Universitätsklinikum Heidelberg
Germany (DE)
Rheinische Friedrich-Wilhelms-Universität Bonn
Germany (DE)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
Woosuk University
Korea, Republic of (KR)
Universitätsklinikum Köln
Germany (DE)
Universität Duisburg-Essen (UDE)
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Germany (DE)
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Universitätsklinikum Heidelberg
Germany (DE)
Rheinische Friedrich-Wilhelms-Universität Bonn
Germany (DE)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
Woosuk University
Korea, Republic of (KR)
Universitätsklinikum Köln
Germany (DE)
Universität Duisburg-Essen (UDE)
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
How to cite
APA:
Schieber, K., Niecke, A., Geiser, F., Erim, Y., Bergelt, C., Büttner-Teleaga, A.,... Weis, J. (2019). The course of cancer-related insomnia: don't expect it to disappear after cancer treatment. Sleep Medicine, 58, 107-113. https://doi.org/10.1016/j.sleep.2019.02.018
MLA:
Schieber, Katharina, et al. "The course of cancer-related insomnia: don't expect it to disappear after cancer treatment." Sleep Medicine 58 (2019): 107-113.
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