Moreira A, Gross S, Kirchberger MC, Erdmann M, Schuler G, Heinzerling L (2019)
Publication Type: Journal article
Publication year: 2019
Book Volume: 144
Pages Range: 1147-1150
Journal Issue: 5
DOI: 10.1002/ijc.31763
Recent studies suggest that the age-related remodeling of the immune system, known as immunosenescence, could impact the efficacy of immune checkpoint inhibitors in leukemia or nonsmall cell lung cancer. We investigated whether senescence markers can predict response to checkpoint inhibitor therapy in melanoma patients. The peripheral blood of patients with newly diagnosed, untreated metastatic melanoma was analyzed by flow cytometry to correlate the frequency of senescence markers with clinical response as measured by RECIST after 12 weeks of treatment with immune checkpoint inhibitors. The loss of surface markers CD27 and CD28 or the expression of Tim-3 and CD57 on T cells was associated with resistance to checkpoint inhibitor blockade, presenting these phenotypes as possible predictive biomarkers for checkpoint inhibitor therapy. Immunosenescence seems to impact on the response to checkpoint inhibitor therapy in melanoma patients. Thus, lymphocyte phenotyping for senescence markers, with the introduction of immunosenescence panels, could be predictive for checkpoint inhibitor response.
APA:
Moreira, A., Gross, S., Kirchberger, M.C., Erdmann, M., Schuler, G., & Heinzerling, L. (2019). Senescence markers: Predictive for response to checkpoint inhibitors. International Journal of Cancer, 144(5), 1147-1150. https://doi.org/10.1002/ijc.31763
MLA:
Moreira, Alvaro, et al. "Senescence markers: Predictive for response to checkpoint inhibitors." International Journal of Cancer 144.5 (2019): 1147-1150.
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