Interactions of zinc(II) complexes with 5′-GMP and their cytotoxic activity

Soldatovic TV, Selimovic E, Smit B, Asanin D, Planojevic NS, Markovic SD, Puchta R, Alzoubi BM (2019)

Publication Type: Journal article

Publication year: 2019


Book Volume: 72

Pages Range: 690-706

Journal Issue: 4

DOI: 10.1080/00958972.2019.1569229


The mechanism of substitution from tetrahedral [ZnCl 2 (en)] and square-pyramidal [ZnCl 2 (terpy)] complexes (where en = 1,2-diaminoethane or ethylenediamine and terpy = 2,2′:6′,2′′-terpyridine) by guanosine-5′-monophosphate (5′-GMP) have been investigated by 1 H NMR spectroscopy. The substitution reaction of [ZnCl 2 (terpy)] complex is faster than the reaction of [ZnCl 2 (en)], which was finished after 48 h. Information about the structures of the final products in solution were obtained from the DFT calculations (B3LYP/6-31G(d)) and experimental 1 H NMR data acquired during the course of the reaction. The cytotoxic activity of zinc(II) complexes was tested on human breast cancer cell line MDA-MB-231, human colon cancer cell line HCT-116 and normal human lung fibroblast cell line MRC-5. Both complexes reduced cell viabilities, while [ZnCl 2 (terpy)] was significantly cytotoxic on MDA-MB-231 after 72 h, and HCT-116 after 24 h without dose dependence. The differences in reactivity toward 5′-GMP and cytotoxic activity of Zn(II) complexes may be attributed to the very stable square-pyramidal geometry of [ZnCl 2 (terpy)] in solution, while weak ligand effect of the en compared to the terpy affected slow interaction of tetrahedral [ZnCl 2 (en)] complex with the target bio-molecule.

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Soldatovic, T.V., Selimovic, E., Smit, B., Asanin, D., Planojevic, N.S., Markovic, S.D.,... Alzoubi, B.M. (2019). Interactions of zinc(II) complexes with 5′-GMP and their cytotoxic activity. Journal of Coordination Chemistry, 72(4), 690-706.


Soldatovic, Tanja V., et al. "Interactions of zinc(II) complexes with 5′-GMP and their cytotoxic activity." Journal of Coordination Chemistry 72.4 (2019): 690-706.

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