Electrospun Polyhydroxybutyrate/Poly(ϵ-caprolactone)/58S Sol-Gel Bioactive Glass Hybrid Scaffolds with Highly Improved Osteogenic Potential for Bone Tissue Engineering

Ding Y, Li W, Mueller T, Schubert DW, Boccaccini AR, Yao Q, Roether J (2016)

Publication Language: English

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2016

Journal

ACS Applied Materials and Interfaces American Chemical Society

Publisher: American Chemical Society

Book Volume: 8

Pages Range: 17098-17108

Journal Issue: 27

URI: https://www.ncbi.nlm.nih.gov/pubmed/27295496

DOI: 10.1021/acsami.6b03997

Abstract

Electrospinning of biopolymer and inorganic substances is one of the efficient ways to combine various advantageous properties in one single fibrous structure with potential for tissue engineering applications. In the present study, to integrate the high stiffness of polyhydroxybutyrate (PHB), the flexibility of poly(ε-caprolactone) (PCL) and the bioactivity of 58S bioactive glass, PHB/PCL/58S sol-gel bioactive glass hybrid scaffolds were fabricated using combined electrospinning and sol-gel method. Physical features such as fiber diameter distribution, mechanical strength and Young's modulus were characterized thoroughly. FTIR analysis demonstrated the successful incorporation of 58S bioactive glass into the blend polymers, which greatly improved the hydrophilicity of PHB/PCL fibermats. The primary biological response of MG-63 osteoblast-like cells on the prepared fibrous scaffolds was evaluated, proving that the 58S glass sol containing hybrid scaffold were not only favorable to MG-63 cell adhesion but also slightly enhanced cell viability and significantly increased alkaline phosphate activity .

Authors with CRIS profile

Yaping Ding Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) (LSP) Wei Li Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Dirk Schubert Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) (LSP) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Judith Roether Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) (LSP)

Involved external institutions

Wenzhou Medical University / 温州医科大学 (WMU) CN China (CN)

How to cite

APA:

Ding, Y., Li, W., Mueller, T., Schubert, D.W., Boccaccini, A.R., Yao, Q., & Roether, J. (2016). Electrospun Polyhydroxybutyrate/Poly(ϵ-caprolactone)/58S Sol-Gel Bioactive Glass Hybrid Scaffolds with Highly Improved Osteogenic Potential for Bone Tissue Engineering. ACS Applied Materials and Interfaces, 8(27), 17098-17108. https://doi.org/10.1021/acsami.6b03997

MLA:

Ding, Yaping, et al. "Electrospun Polyhydroxybutyrate/Poly(ϵ-caprolactone)/58S Sol-Gel Bioactive Glass Hybrid Scaffolds with Highly Improved Osteogenic Potential for Bone Tissue Engineering." ACS Applied Materials and Interfaces 8.27 (2016): 17098-17108.

BibTeX: Download