Corrections of myocardial tissue sodium concentration measurements in human cardiac23Na MRI at 7 Tesla

Lott J, Platt T, Niesporek SC, Paech D, G. R. Behl N, Niendorf T, Bachert P, Ladd ME, Nagel AM (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Magnetic Resonance in Medicine Wiley

Book Volume: 82

Pages Range: 159-173

Journal Issue: 1

DOI: 10.1002/mrm.27703

Abstract

Purpose: To quantify the tissue sodium concentration (TSC) in cardiac 23 Na MRI. To evaluate the influence of different correction methods on the measured myocardial TSC. Methods: 23 Na MRI of four healthy subjects was conducted at a whole-body 7T MRI system using an oval-shaped 23 Na birdcage coil. Data acquisition was performed with a density-adapted 3D radial pulse sequence using a golden angle projection scheme. 1 H MRI data were acquired at a 3T MRI system to generate a myocardial mask. Retrospective cardiac and respiratory gating were used to reconstruct 23 Na MRI data in the diastolic phase and exhaled state. B 0 and B 1 inhomogeneity and partial volume (PV) effects were corrected. Relaxation times and TSC of ex vivo blood samples and calf muscle were determined. These values were used in the PV correction to estimate myocardial TSC, which was compared with the measured TSC of calf muscle. Results: Without any correction the measured myocardial TSC was (54 ± 5) mM. The applied correction methods reduced these values by (48 ± 5)% to (29 ± 3) mM, where PV correction had the largest effect (reduction of (34 ± 1)%). Respiratory and cardiac motion gating decreased the concentrations by (11 ± 1)%. With the applied setup, the corrections of B 0 and B 1 inhomogeneity (reduction of (3 ± 2)%) had negligible influences on TSC values. The resulting myocardial TSC was approximately 1.4-fold higher than the measured TSC of calf muscle tissue of the same healthy subjects ((20 ± 3) mM). Conclusion: For quantitative human cardiac 23 Na MRI several corrections are needed and ranked for our setup: PV correction, respiratory and cardiac gating, correction for B 1 inhomogeneity effects.

Authors with CRIS profile

Armin Michael Nagel Professur für metabolische und funktionelle MR-Bildgebung

Involved external institutions

Southern Medical University / 南方医科大学 CN China (CN) MRI.TOOLS GmbH DE Germany (DE)

How to cite

APA:

Lott, J., Platt, T., Niesporek, S.C., Paech, D., G. R. Behl, N., Niendorf, T.,... Nagel, A.M. (2019). Corrections of myocardial tissue sodium concentration measurements in human cardiac23Na MRI at 7 Tesla. Magnetic Resonance in Medicine, 82(1), 159-173. https://doi.org/10.1002/mrm.27703

MLA:

Lott, Johanna, et al. "Corrections of myocardial tissue sodium concentration measurements in human cardiac23Na MRI at 7 Tesla." Magnetic Resonance in Medicine 82.1 (2019): 159-173.

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