DNA methylation and chromatin modifiers in colorectal cancer

Vymetalkova V, Vodicka P, Vodenkova S, Alonso S, Schneider-Stock R (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Molecular Aspects of Medicine Elsevier

DOI: 10.1016/j.mam.2019.04.002

Abstract

Colorectal carcinogenesis is a multistep process involving the accumulation of genetic alterations over time that ultimately leads to disease progression and metastasis. Binding of transcription factors to gene promoter regions alone cannot explain the complex regulation pattern of gene expression during this process. It is the chromatin structure that allows for a high grade of regulatory flexibility for gene expression. Posttranslational modifications on histone proteins such as acetylation, methylation, or phosphorylation determine the accessibility of transcription factors to DNA. DNA methylation, a chemical modification of DNA that modulates chromatin structure and gene transcription acts in concert with these chromatin conformation alterations. Another epigenetic mechanism regulating gene expression is represented by small non-coding RNAs. Only very recently epigenetic alterations have been included in molecular subtype classification of colorectal cancer (CRC). In this chapter, we will provide examples of the different epigenetic players, focus on their role for epithelial-mesenchymal transition and metastatic processes and discuss their prognostic value in CRC.

Authors with CRIS profile

Regine Schneider-Stock Professur für Experimentelle Tumorpathologie

Involved external institutions

Institute of Experimental Medicine CAS CZ Czech Republic (CZ) Health Sciences Research Institute of the “Germans Trias i Pujol” Foundation (IGTP) ES Spain (ES)

How to cite

APA:

Vymetalkova, V., Vodicka, P., Vodenkova, S., Alonso, S., & Schneider-Stock, R. (2019). DNA methylation and chromatin modifiers in colorectal cancer. Molecular Aspects of Medicine. https://doi.org/10.1016/j.mam.2019.04.002

MLA:

Vymetalkova, Veronika, et al. "DNA methylation and chromatin modifiers in colorectal cancer." Molecular Aspects of Medicine (2019).

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