Electrophoretic Deposition of Bioadaptive Drug Delivery Coatings on Magnesium Alloy for Bone Repair

Qi H, Heise S, Zhou J, Schuhladen K, Yang Y, Cui N, Dong R, Virtanen S, Chen Q, Boccaccini AR, Lu T (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Book Volume: 11

Pages Range: 8625-8634

Journal Issue: 8

DOI: 10.1021/acsami.9b01227

Abstract

Biodegradable polymer coatings on magnesium alloys are attractive, as they can provide corrosion resistance as well as additional functions for biomedical applications, e.g., drug delivery. A gelatin nanospheres/chitosan (GNs/CTS) composite coating on WE43 substrate was fabricated by electrophoretic deposition with simvastatin (SIM) loaded into the GNs. Apart from a sustained drug release over 28 days, an anticorrosion behavior of the coated WE43 substrates was confirmed by electrochemical tests. Both the degradation and corrosion rates of the coated substrate were significantly minimized in contrast to bare WE43. The cytocompatibility of the coated samples was analyzed both quantitatively and qualitatively. Additionally, the osteogenic differentiation of MC3T3El cells on SIM-containing coatings was assessed by measuring the expression of osteogenic genes and related proteins, alkaline phosphatase (ALP) activity, and extracellular matrix mineralization, showing that the SIM-loaded composite coating could upregulate the expression of osteogenic genes and related proteins, promote ALP activity, and enhance extracellular matrix mineralization. In summary, the SIM-loaded GNs/CTS composite coatings were able to enhance the corrosion resistance of the WE43 substrate and promote osteogenic activity, thus demonstrating a promising coating system for modifying the surface of magnesium alloys targeted for orthopedic applications.

Authors with CRIS profile

Involved external institutions

Northwestern Polytechnical University / 西北工业大学 (NPU/NWPU) China (CN) Harbin Engineering University (HEU) / 哈尔滨工程大学 China (CN)

How to cite

APA:

Qi, H., Heise, S., Zhou, J., Schuhladen, K., Yang, Y., Cui, N.,... Lu, T. (2019). Electrophoretic Deposition of Bioadaptive Drug Delivery Coatings on Magnesium Alloy for Bone Repair. ACS Applied Materials and Interfaces, 11(8), 8625-8634. https://doi.org/10.1021/acsami.9b01227

MLA:

Qi, Hongfei, et al. "Electrophoretic Deposition of Bioadaptive Drug Delivery Coatings on Magnesium Alloy for Bone Repair." ACS Applied Materials and Interfaces 11.8 (2019): 8625-8634.

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