Functional and Genetic Analysis of Plectin in Skin and Muscle
Rezniczek GA, Winter L, Walko G, Wiche G (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 569
Pages Range: 235-59
DOI: 10.1016/bs.mie.2015.05.003
Abstract
Plectin is a large cytoskeletal linker protein with a multitude of functions affecting various cellular processes. It is expressed as several different isoforms from a highly complex gene. Both, this transcript diversity (mainly caused by short 5'-sequences contained in alternative first exons) and the size (>500 kDa) of the resulting proteins, present considerable challenges to plectin researchers. In this chapter, we will consider these problems and offer advice on how to tackle them best. As plectin has been studied most extensively in skin and muscle, we will focus on these types of tissues and describe some selected methods in detail. Foremost, however, we aim to give the readers some good pointers to available tools and into the existing literature.
Involved external institutions
Ruhr-Universität Bochum (RUB)
Germany (DE)
King’s College London
United Kingdom (GB)
Medizinische Universität Wien
Austria (AT)
Germany (DE)
King’s College London
United Kingdom (GB)
Medizinische Universität Wien
Austria (AT)
How to cite
APA:
Rezniczek, G.A., Winter, L., Walko, G., & Wiche, G. (2016). Functional and Genetic Analysis of Plectin in Skin and Muscle. Methods in Enzymology, 569, 235-59. https://doi.org/10.1016/bs.mie.2015.05.003
MLA:
Rezniczek, Guenther A., et al. "Functional and Genetic Analysis of Plectin in Skin and Muscle." Methods in Enzymology 569 (2016): 235-59.
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