Lithographically patterned silicon nanowire arrays for matrix free LDI-TOF/MS analysis of lipids

Muck A, Stelzner T, Huebner U, Christiansen S, Svatos A (2010)

Publication Type: Journal article

Publication year: 2010

Journal

Lab on A Chip Royal Society of Chemistry

Book Volume: 10

Article Number: 320

Journal Issue: 3

DOI: 10.1039/B913212K

Abstract

Silicon nanowire arrays were patterned onto silicon chips by a combination of lithography and chemical vapor deposition using the vapor-liquid-solid growth method. Thus, highly reproducible sample deposition zones were obtained that were used for laser desorption ionization (LDI) mass spectrometric analysis of lipidic species with lithium salts as dopants. Using a conventional UV laser (337 nm), hydrocarbons and numerous lipids (triglycerides, diglycerides, wax esters) could be effectively lithiated yielding [M + Li]+ ions. Upon doping with lithium hydroxide the SiNW arrays yielded high signal-to-noise ratios with low limits of detection (e.g. 750 pg tripalmitin on target with S/N 5) and efficient ionization for a range of fatty acids (FA), mono-, di- and triglycerides and hydrocarbons (HC), in the form of [FA $-$ H + 2Li]+, [mono- or diglyceride $-$ H$_2$O + Li]+, or [triglyceride + Li]+ and [HC + Li]+, respectively. It is expected that these chips will find a broad range of applications in the analysis of natural compounds and food control.

Additional Organisation(s)

Exzellenz-Cluster Engineering of Advanced Materials (EAM)

Involved external institutions

Max-Planck-Institut für chemische Ökologie / Max Planck Institute for Chemical Ecology DE Germany (DE) Leibniz-Institut für Photonische Technologien e.V. DE Germany (DE)

How to cite

APA:

Muck, A., Stelzner, T., Huebner, U., Christiansen, S., & Svatos, A. (2010). Lithographically patterned silicon nanowire arrays for matrix free LDI-TOF/MS analysis of lipids. Lab on A Chip, 10(3). https://doi.org/10.1039/B913212K

MLA:

Muck, Alexander, et al. "Lithographically patterned silicon nanowire arrays for matrix free LDI-TOF/MS analysis of lipids." Lab on A Chip 10.3 (2010).

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