Stonawski V, Frey S, Golub Y, Moll G, Heinrich H, Eichler A (2018)
Publication Type: Journal article
Publication year: 2018
Book Volume: 46
Pages Range: 155-167
Journal Issue: 2
DOI: 10.1024/1422-4917/a000515
Besides typical physical and hormonal changes during pregnancy, this life period is often associated with an increased emotional and mental stress for women. For the child, the time in utero is regarded as a critical developmental period since adverse stimuli during pregnancy can have lasting consequences for the fetal and postnatal health and development. Thus, prenatal depression, anxiety and stress are considered as risk factors for developmental delay, emotional and behavioral problems. Epigenetic modifications, especially modifications in DNA methylation, are discussed as a possible biological mechanism that could explain the association between prenatal emotional stress and altered developmental and health outcomes of the child. This review summarizes evidence for DNA methylation changes related to prenatal emotional stress from studies with a candidate-gene approach as well as epigenome-wide association studies. Problematic issues are discussed and recommendations for future research are presented.
APA:
Stonawski, V., Frey, S., Golub, Y., Moll, G., Heinrich, H., & Eichler, A. (2018). Epigenetic modifications in children associated with maternal emotional stress during pregnancy. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 46(2), 155-167. https://doi.org/10.1024/1422-4917/a000515
MLA:
Stonawski, Valeska, et al. "Epigenetic modifications in children associated with maternal emotional stress during pregnancy." Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie 46.2 (2018): 155-167.
BibTeX: Download