Role of L-Particles during Herpes Simplex Virus Infection
Heilingloh C, Krawczyk A (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 8
Abstract
Infection of eukaryotic cells with α-herpesviruses results in the formation and secretion of infectious heavy particles (virions; H-particles) and non-infectious light particles (L-particles). Herpes simplex virus type 1 (HSV-1) H-particles consist of a genome-containing capsid surrounded by tegument proteins and a glycoprotein-rich lipid bilayer. Non-infectious L-particles are composed mainly of envelope and tegument proteins and are devoid of capsids and viral DNA. L-particles were first described in the early nineties and from then on investigated for their formation and role during virus infection. The development and secretion of L-particles occur simultaneously to the assembly of complete viral particles. HSV-1 L-particles are assembled by budding of condensed tegument into Golgi-delivered vesicles and are capable of delivering their functional content to non-infected cells. Thereby, HSV-1 L-particles contribute to viral pathogenesis within the infected host by enhancing virion infectivity and providing immune evasion functions. In this review we discuss the emergence of HSV-1 L-particles during virus replication and their biological functions described thus far.
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Germany (DE)How to cite
APA:
Heilingloh, C., & Krawczyk, A. (2017). Role of L-Particles during Herpes Simplex Virus Infection. Frontiers in Microbiology, 8. https://doi.org/10.3389/fmicb.2017.02565
MLA:
Heilingloh, Christiane, and Adalbert Krawczyk. "Role of L-Particles during Herpes Simplex Virus Infection." Frontiers in Microbiology 8 (2017).
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