Microporous structure and drug release kinetics of polymeric nanoparticles.

Sant S, Thommes M, Hildgen P (2008)

Publication Type: Journal article, Original article

Subtype: other

Publication year: 2008


Publisher: American Chemical Society

Book Volume: 24

Pages Range: 280-287-287

Journal Issue: 1

DOI: 10.1021/la702244w


The aim of the present study was to characterize pegylated nanoparticles (NPs) for their microporosity and study the effect of microporosity on drug release kinetics. Blank and drug-loaded NPs were prepd. from three different pegylated polymers, namely, poly(ethylene glycol)1%-graft-poly(D,L)-lactide, poly(ethylene glycol)5%-graft-poly(D,L)-lactide, and the multiblock copolymer (poly(D,L)-lactide-block-poly(ethylene glycol)-block-poly(D,L)-lactide)n. These NPs were characterized for their microporosity using nitrogen adsorption isotherms. NPs of the multiblock copolymer showed the least microporosity and Brunauer-Emmett-Teller (BET) surface area, and that of PEG1%-g-PLA showed the max. Based on these results, the structural organization of poly(D,L)-lactide (PLA) and poly(ethylene glycol) (PEG) chains inside the NPs was proposed and was validated with differential scanning calorimetry (DSC) and XPS surface anal. An in vitro drug release study revealed that PEG1%-g-PLA NPs exhibited slower release despite their higher surface area and microporosity. This was attributed to the presence of increased microporosity forming tortuous internal structures, thereby hindering drug diffusion from the matrix. Thus, it was concluded that the microporous structure of NPs, which is affected by the mol. architecture of polymers, dets. the release rate of the encapsulated drug. [on SciFinder(R)]

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Sant, S., Thommes, M., & Hildgen, P. (2008). Microporous structure and drug release kinetics of polymeric nanoparticles. Langmuir, 24(1), 280-287-287. https://doi.org/10.1021/la702244w


Sant, Shilpa, Matthias Thommes, and Patrice Hildgen. "Microporous structure and drug release kinetics of polymeric nanoparticles." Langmuir 24.1 (2008): 280-287-287.

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