Transdermal scopolamine for the prevention of a salivary fistula after parotidectomy

Mantsopoulos K, Goncalves M, Iro H (2018)

Publication Type: Journal article

Publication year: 2018

Journal

British Journal of Oral and Maxillofacial Surgery Elsevier

Book Volume: 56

Pages Range: 212-215

Journal Issue: 3

DOI: 10.1016/j.bjoms.2018.01.014

Abstract

Our aim was to investigate whether perioperative transdermal application of scopolamine could help to prevent fistulas after parotidectomy, and to this end we retrospectively studied the records of all patients (n=645) who had benign parotid tumours treated by partial parotidectomy between 2011 and 2016. We found that scopolamine led to a significant decrease in the incidence of salivary fistulas from 54/371(15%) in the group not given it to 10/274 (4%) in the group given it (p<0.0001). The "number needed to treat" was 9.17. There was a relatively low incidence of all adverse effects after scopolamine. Our results are encouraging. Thorough consideration of the contraindications and a knowledge of the potential adverse effects are crucial for its successful implementation.

Authors with CRIS profile

Konstantinos Mantsopoulos Department of Otorhinolaryngology – Head and Neck Surgery Miguel Goncalves Department of Otorhinolaryngology – Head and Neck Surgery Heinrich Iro Lehrstuhl für Hals-, Nasen- und Ohrenheilkunde

How to cite

APA:

Mantsopoulos, K., Goncalves, M., & Iro, H. (2018). Transdermal scopolamine for the prevention of a salivary fistula after parotidectomy. British Journal of Oral and Maxillofacial Surgery, 56(3), 212-215. https://doi.org/10.1016/j.bjoms.2018.01.014

MLA:

Mantsopoulos, Konstantinos, Miguel Goncalves, and Heinrich Iro. "Transdermal scopolamine for the prevention of a salivary fistula after parotidectomy." British Journal of Oral and Maxillofacial Surgery 56.3 (2018): 212-215.

BibTeX: Download