Encapsulation of Mesenchymal Stem Cells Improves Vascularization of Alginate-Based Scaffolds.

Steiner D, Lingens L, Fischer L, Köhn K, Detsch R, Boccaccini AR, Fey T, Greil P, Weis C, Beier J, Horch RE, Arkudas A (2018)

Publication Status: Published

Publication Type: Journal article

Publication year: 2018

Journal

Tissue Engineering: Parts A, B, and C Mary Ann Liebert

Book Volume: 24

Pages Range: 1320-1331

Journal Issue: 17-18

DOI: 10.1089/ten.TEA.2017.0496

Abstract

DiI-labeled MSCs/mL ADA-GEL. Four weeks postoperatively, tissue formation and vascularization were investigated by histology and microcomputed tomography. We were able to prove vascularization originating from the AV loop in both groups with statistically significant more vessels in group B containing MSCs. Moreover, encapsulated MSCs promoted biodegradation of the ADA-GEL microcapsules. In the present study, we were able to demonstrate for the first time, the successful vascularization of ADA-GEL microcapsules by means of the AV loop. Furthermore, ADA-GEL displayed a good biocompatibility and encapsulation of MSCs into ADA-GEL microcapsule-enhanced vascularization as well as biodegradation.

Authors with CRIS profile

Dominik Steiner Department of Plastic and Hand Surgery Lara Lingens Department of Plastic and Hand Surgery Laura Fischer Department of Plastic and Hand Surgery Katrin Köhn Department of Plastic and Hand Surgery Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Tobias Fey Lehrstuhl für Glas und Keramik (WW3) Peter Greil Lehrstuhl für Glas und Keramik (WW3) Raymund Horch Professur für Plastische Chirurgie und Handchirurgie Andreas Arkudas Medizinische Fakultät

How to cite

APA:

Steiner, D., Lingens, L., Fischer, L., Köhn, K., Detsch, R., Boccaccini, A.R.,... Arkudas, A. (2018). Encapsulation of Mesenchymal Stem Cells Improves Vascularization of Alginate-Based Scaffolds. Tissue Engineering: Parts A, B, and C, 24(17-18), 1320-1331. https://doi.org/10.1089/ten.TEA.2017.0496

MLA:

Steiner, Dominik, et al. "Encapsulation of Mesenchymal Stem Cells Improves Vascularization of Alginate-Based Scaffolds." Tissue Engineering: Parts A, B, and C 24.17-18 (2018): 1320-1331.

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