The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells
Lafita-Navarro MC, Kim M, Borenstein-Auerbach N, Venkateswaran N, Hao YH, Ray R, Brabletz T, Scaglioni PP, Shay JW, Conacci-Sorrell M (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 32
Pages Range: 1303-1308
Journal Issue: 19-20
Abstract
MYC enhances protein synthesis by regulating genes involved in ribosome biogenesis and protein translation. Here, we show that MYC-induced protein translation is mediated by the transcription factor aryl hydrocarbon receptor (AHR), which is induced by MYC in colonic cells. AHR promotes protein synthesis by activating the transcription of genes required for ribosome biogenesis and protein translation, including OGFOD1 and NOLC1. Using surface sensing of translation (SUnSET) to measure global protein translation, we found that silencing AHR or its targets diminishes protein synthesis. Therefore, targeting AHR or its downstream pathways could provide a novel approach to limit biomass production in MYC-driven tumors.
Authors with CRIS profile
Thomas Brabletz
Lehrstuhl für Experimentelle Medizin mit dem Schwerpunkt Molekulare Pathogeneseforschung
Involved external institutions
University of Texas Southwestern Medical Center (UT Southwestern)
United States (USA) (US)
University of Cincinnati
United States (USA) (US)
United States (USA) (US)
University of Cincinnati
United States (USA) (US)
How to cite
APA:
Lafita-Navarro, M.C., Kim, M., Borenstein-Auerbach, N., Venkateswaran, N., Hao, Y.-H., Ray, R.,... Conacci-Sorrell, M. (2018). The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells. Genes & Development, 32(19-20), 1303-1308. https://doi.org/10.1101/gad.313007.118
MLA:
Lafita-Navarro, M. Carmen, et al. "The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells." Genes & Development 32.19-20 (2018): 1303-1308.
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