Hydration mechanism of a calcium phosphate cement modified with phytic acid

Hurle K, Weichhold J, Brueckner M, Gbureck U, Brueckner T, Götz-Neunhoeffer F (2018)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2018


Publisher: Acta Materialia Inc

Book Volume: 80

Pages Range: 378-389

DOI: 10.1016/j.actbio.2018.09.002


Calcium phosphate cements composed of β-tricalcium phosphate (β-TCP) and phosphoric acid were modified by addition of 5, 10, 12.5, 15 and 20 wt% phytic acid (IP6) related to the β-TCP content and compared to a reference containing 0.5 M citric acid monohydrate solution as setting regulator. The hydration reaction of these cements was investigated by isothermal calorimetry and in-situ X-ray diffraction at 23 °C and 37 °C. The cements were further characterized with respect to their injectability, rheology, zeta potential and time-resolved compressive strength development.

Injectability was strongly improved by IP6 addition, while the maximum effect was already reached by the addition of 5 wt% IP6. This could be clearly related to an increase of the negative zeta potential leading to a mutual repulsion of cement particles. A further increase of the IP6 content had a detrimental effect on initial paste viscosity and shifted the gelation point to earlier time points. IP6 was further proven to act as a retarder for the cement setting reaction, whereas the effect was stronger for higher IP6 concentrations. Additionally, IP6 favoured the formation of monetite instead of brushite and a better mechanical performance compared to the IP6 free reference cement.

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Hurle, K., Weichhold, J., Brueckner, M., Gbureck, U., Brueckner, T., & Götz-Neunhoeffer, F. (2018). Hydration mechanism of a calcium phosphate cement modified with phytic acid. Acta Biomaterialia, 80, 378-389. https://doi.org/10.1016/j.actbio.2018.09.002


Hurle, Katrin, et al. "Hydration mechanism of a calcium phosphate cement modified with phytic acid." Acta Biomaterialia 80 (2018): 378-389.

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