Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading?

Breyer J, Otto W, Burger M, Hartmann A, Rubenwolf PC (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Bladder Cancer IOS Press

Book Volume: 3

Pages Range: 31-34

Journal Issue: 1

DOI: 10.3233/BLC-160082

Abstract

We have previously provided molecular evidence of expression of aquaporin 3 (AQP3) in normal human urothelium and in UBC of various stages. Whereas former studies demonstrated that loss of AQP3 was associated with invasive and high-grade disease and worse progression-free and cancer-specific survival, this report investigates the expression of AQP3 in associated CIS. Contrary to what we had expected, all CIS specimens were shown to exhibit strong AQP3 expression, suggesting loss of AQP3 in UBC is primarily associated with the ability of tumor cells for invasion but not with grading as sign of dedifferentiation.

Authors with CRIS profile

Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Universität Regensburg DE Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE)

How to cite

APA:

Breyer, J., Otto, W., Burger, M., Hartmann, A., & Rubenwolf, P.C. (2017). Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading? Bladder Cancer, 3(1), 31-34. https://doi.org/10.3233/BLC-160082

MLA:

Breyer, Johannes, et al. "Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading?" Bladder Cancer 3.1 (2017): 31-34.

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