Clinical characteristics and outcome of 60 pediatric patients with malignant melanoma registered with the German Pediatric Rare Tumor Registry (STEP)
Offenmüller S, Leiter U, Bernbeck B, Garbe C, Eigentler T, Borkhardt A, Classen CF, Corbacioglu S, Dirksen U, Ebetsberger-Dachs G, Heinzerling L, Jorch N, Kuhlen M, Lawlor J, Niggli F, Streiter M, Schneider DT, Brecht I (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 229
Pages Range: 322-328
Journal Issue: 6
Abstract
Background Malignant melanoma (MM) is a common malignancy in adults while it is rare in children. Thus, information on clinical behavior of pediatric MM is incomplete. Patients The German Pediatric Rare Tumor Registry (STEP) presents a prospective analysis of 60 childhood MM cases diagnosed between June 2006 and December 2014. Method Patients' ages ranged between 0 and 17 years at initial diagnosis (median age 9.6 years). Information on patient's and tumor characteristics was obtained by standardized documentation. Three-year overall survival (OS) and event-free survival (EFS) were estimated by the Kaplan-Meier test. Results Follow-up ranged from 0 to 116 months with a median of 36.5 months, however, univariate analysis was performed for 46 cases with a follow-up > 3 months, only. Cases with spitzoid histotype (40%) did not show a significantly different outcome compared to cases with non-spitzoid MM. Breslow thickness ≤ 2.00 mm was identified in 30% of the cases and 18% were Clark level I to III. Adjuvant therapy was used in 45% of cases. OS at 3 years was 100%, EFS 95.2%. Conclusion We present a series of cases with a high number of spitzoid malignant melanoma and advanced pediatric melanoma, but surprisingly good overall survival rates. Spitzoid and non-spitzoid MM do not differ in clinical behavior and survival.
Authors with CRIS profile
Sonja Diez
Department of Paediatrics and Adolescent Medicine
Lucie Heinzerling
Department of Dermatology
Involved external institutions
Kepler Universitätsklinikum (KUK)
Austria (AT)
Evangelisches Krankenhaus Bielefeld
Germany (DE)
Universitätsklinikum Essen
Germany (DE)
Klinikum Dortmund
Germany (DE)
Universität Regensburg
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Universitätsklinikum Düsseldorf
Germany (DE)
SLK-Kliniken Heilbronn GmbH
Germany (DE)
Universitätsmedizin Rostock
Germany (DE)
Universitäts-Kinderspital Zürich
Switzerland (CH)
Universitätsklinikum Magdeburg A.ö.R.
Germany (DE)
Austria (AT)
Evangelisches Krankenhaus Bielefeld
Germany (DE)
Universitätsklinikum Essen
Germany (DE)
Klinikum Dortmund
Germany (DE)
Universität Regensburg
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Universitätsklinikum Düsseldorf
Germany (DE)
SLK-Kliniken Heilbronn GmbH
Germany (DE)
Universitätsmedizin Rostock
Germany (DE)
Universitäts-Kinderspital Zürich
Switzerland (CH)
Universitätsklinikum Magdeburg A.ö.R.
Germany (DE)
How to cite
APA:
Offenmüller, S., Leiter, U., Bernbeck, B., Garbe, C., Eigentler, T., Borkhardt, A.,... Brecht, I. (2017). Clinical characteristics and outcome of 60 pediatric patients with malignant melanoma registered with the German Pediatric Rare Tumor Registry (STEP). Klinische Pädiatrie, 229(6), 322-328. https://doi.org/10.1055/s-0043-118662
MLA:
Offenmüller, Sonja, et al. "Clinical characteristics and outcome of 60 pediatric patients with malignant melanoma registered with the German Pediatric Rare Tumor Registry (STEP)." Klinische Pädiatrie 229.6 (2017): 322-328.
BibTeX: Download