Comparison of standard- and high-dose intracoronary adenosine for the measurement of coronary fractional flow reserve (FFR)

Röther J, Achenbach S, Tröbs M, Blachutzik F, Nef H, Schlundt C, Marwan M (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Clinical Research in Cardiology Springer Verlag (Germany)

Book Volume: 105

Pages Range: 1003-1010

Journal Issue: 12

DOI: 10.1007/s00392-016-1010-0

Abstract

BACKGROUND: Measurement of fractional flow reserve (FFR) by intravenous infusion or intracoronary injection of adenosine is the reference method to determine the hemodynamic relevance of coronary artery stenoses. The goal of this prospective study was to compare standard (40 µg adenosine for the right and 80 µg for the left coronary artery) to high doses of intracoronary adenosine for FFR measurement. METHODS AND RESULTS: In 130 intermediate coronary artery stenoses, two sequential FFR measurements were performed with standard-dose intracoronary application of adenosine (40 µg for the right and 80 μg for the left coronary artery), followed by one FFR measurement with a bolus of 200 μg for the right and 400 μg for the left coronary artery. There was strong correlation (r = 0.97, p < 0.001) between FFR values determined with standard-dose adenosine (0.86 ± 0.08) versus high-dose adenosine (0.85 ± 0.08). High-dose adenosine did not yield FFR values ≤0.80 or ≤0.75 significantly more frequently than standard-dose adenosine. Patients reported more discomfort after high-dose adenosine application compared to standard-dose adenosine (p < 0.001). CONCLUSIONS: For FFR measurements with intracoronary adenosine injection, results achieved with doses of 40 µg adenosine for the right and 80 µg for the left coronary artery display no clinically relevant difference to doses of 200 and 400 µg, respectively.

Authors with CRIS profile

Jens Röther Department of Medicine 2 – Cardiology and Angiology Stephan Achenbach Department of Medicine 2 – Cardiology and Angiology Monique Tröbs Department of Medicine 2 – Cardiology and Angiology Christian Schlundt Department of Medicine 2 – Cardiology and Angiology Mohamed Marwan Department of Medicine 2 – Cardiology and Angiology

Involved external institutions

Justus-Liebig-Universität Gießen DE Germany (DE)

How to cite

APA:

Röther, J., Achenbach, S., Tröbs, M., Blachutzik, F., Nef, H., Schlundt, C., & Marwan, M. (2016). Comparison of standard- and high-dose intracoronary adenosine for the measurement of coronary fractional flow reserve (FFR). Clinical Research in Cardiology, 105(12), 1003-1010. https://doi.org/10.1007/s00392-016-1010-0

MLA:

Röther, Jens, et al. "Comparison of standard- and high-dose intracoronary adenosine for the measurement of coronary fractional flow reserve (FFR)." Clinical Research in Cardiology 105.12 (2016): 1003-1010.

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