A new novolimus-eluting bioresorbable coronary scaffold: Present status and future clinical perspectives
Nef HM, Wiebe J, Foin N, Blachutzik F, Doerr O, Toyloy S, Hamm CW (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 227
Pages Range: 127-133
DOI: 10.1016/j.ijcard.2016.11.033
Abstract
The DESolve® scaffold (Elixir Medical Corporation, Sunnyvale, California, USA) is manufactured from a poly-l-lactide based polymer and elutes an anti-proliferative, anti-inflammatory drug, Novolimus from a poly-l-lactide based topcoat mixture. The strut thickness is 150μm and the scaffold has platinum-iridium radiopaque markers at both ends. Radial support is available during the early time period to prevent recoil. The scaffold biodegrades within 1year (>90% reduction in molecular weight) and then completely bioresorbs within 2years. The DESolve® scaffold permits a wide range of expansion with a consequently reduced risk for strut fracture. Lumen and scaffold enlargement is observed within 3-6months in both preclinical and clinical studies potentially allowing for the scaffolded region to respond to vasoactive stimuli. The device has a unique property of self-correction observed in bench top studies, which in clinical practice has the potential to eliminate minor malapposition following deployment.
Involved external institutions
Justus-Liebig-Universität Gießen
Germany (DE)
National Heart Research Institute Singapore (NHRIS)
Singapore (SG)
Elixir Medical
United States (USA) (US)
Technische Universität München (TUM)
Germany (DE)
Germany (DE)
National Heart Research Institute Singapore (NHRIS)
Singapore (SG)
Elixir Medical
United States (USA) (US)
Technische Universität München (TUM)
Germany (DE)
How to cite
APA:
Nef, H.M., Wiebe, J., Foin, N., Blachutzik, F., Doerr, O., Toyloy, S., & Hamm, C.W. (2017). A new novolimus-eluting bioresorbable coronary scaffold: Present status and future clinical perspectives. International Journal of Cardiology, 227, 127-133. https://doi.org/10.1016/j.ijcard.2016.11.033
MLA:
Nef, Holger M., et al. "A new novolimus-eluting bioresorbable coronary scaffold: Present status and future clinical perspectives." International Journal of Cardiology 227 (2017): 127-133.
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