The Definition, Rationale, and Effects of Thresholding in OCT Angiography

Cole ED, Moult EM, Dang S, Choi W, Ploner S, Lee B, Louzada RN, Novais EA, Schottenhamml J, Husvogt L, Maier A, Fujimoto JG, Waheed NK, Duker JS (2017)

Publication Type: Journal article, Original article

Publication year: 2017


Book Volume: 1/2017

Pages Range: 435-447

Journal Issue: 5


DOI: 10.1016/j.oret.2017.01.019



To examine the definition, rationale, and effects of thresholding in OCT angiography (OCTA).


A theoretical description of OCTA thresholding in combination with qualitative and quantitative analysis of the effects of OCTA thresholding in eyes from a retrospective case series.


Four eyes were qualitatively examined: 1 from a 27-year-old control, 1 from a 78-year-old exudative age-related macular degeneration (AMD) patient, 1 from a 58-year-old myopic patient, and 1 from a 77-year-old nonexudative AMD patient with geographic atrophy (GA). One eye from a 75-year-old nonexudative AMD patient with GA was quantitatively analyzed.

Main Outcome Measures

A theoretical thresholding model and a qualitative and quantitative description of the dependency of OCTA on thresholding level.


Due to the presence of system noise, OCTA thresholding is a necessary step in forming OCTA images; however, thresholding can complicate the relationship between blood flow and OCTA signal.


Thresholding in OCTA can cause significant artifacts, which should be considered when interpreting and quantifying OCTA images.

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How to cite


Cole, E.D., Moult, E.M., Dang, S., Choi, W., Ploner, S., Lee, B.,... Duker, J.S. (2017). The Definition, Rationale, and Effects of Thresholding in OCT Angiography. Ophthalmology Retina, 1/2017(5), 435-447.


Cole, Emily D., et al. "The Definition, Rationale, and Effects of Thresholding in OCT Angiography." Ophthalmology Retina 1/2017.5 (2017): 435-447.

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