Choroidal Neovascularization Analyzed on Ultra-High Speed Swept Source Optical Coherence Tomography Angiography Compared to Spectral Domain Optical Coherence Tomography Angiography

Louzada RN, Novais EA, Adhi M, Cole ED, Moult EM, Husvogt L, Witkin AJ, Baumal CR, Fujimoto JG, Duker JS, Waheed NK (2016)

Publication Language: English

Publication Type: Conference contribution

Publication year: 2016

Publisher: ARVO

City/Town: ARVO

Book Volume: 57

Edition: 12

Conference Proceedings Title: Investigative Ophthalmology & Visual Science

Event location: Seattle, WA, USA US

URI: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2016/Louzada16-CNA.pdf

Abstract

Purpose : Cross-sectional, observational study to compare visualization of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) using an ultra-high speed swept-source (SS)-optical coherence tomography angiography (OCTA) prototype versus a spectral-domain (SD)-OCTA device.

Methods : Patients were imaged on SD-OCT and SS-OCT devices on the same day. The SD-OCT device employed is the RTVue Avanti that operates at ~840nm wavelength and 70,000 A-scans/second. The SS-OCT device used is an ultra-high speed long-wavelength prototype that operates at ~1050nm wavelength and 400,000 A-scans/second. Two observers independently measured the CNV area on OCTA en face images from the two devices using ImageJ. The non-parametric Wilcoxon signed-rank test was used to compare area measurements.

Results : Fourteen eyes from 13 patients were enrolled. The CNV in 11 eyes (78.6%) were classified as type-1, 2 eyes (14.3%) as type-2, and 1 eye (7.1%) as mixed type. The mean CNV areas measured using SS-OCT and SD-OCT 3mm x 3mm OCTA were 0.949 ± 1.168mm2 and 0.340 ± 0.301mm2, respectively (p=0.001). For the 6mm x 6mm OCTA the CNV areas using SS-OCT and SD-OCT were 1.218 ± 1.284mm2 and 0.604 ± 0.597mm2, respectively (p=0.0019). The field of view did not significantly affect the measured CNV area (p=0.19 and p=0.18 for SS-OCT and SD-OCT respectively).

Conclusions : SS-OCTA measurements yielded significantly larger CNV areas than SD-OCTA. It is possible that SS-OCTA is better able to demarcate the full extent of CNV vasculature.

Authors with CRIS profile

Lennart Husvogt Lehrstuhl für Informatik 5 (Mustererkennung)

Involved external institutions

Tufts Medical Center US United States (USA) (US) Massachusetts Institute of Technology (MIT) US United States (USA) (US)

How to cite

APA:

Louzada, R.N., Novais, E.A., Adhi, M., Cole, E.D., Moult, E.M., Husvogt, L.,... Waheed, N.K. (2016). Choroidal Neovascularization Analyzed on Ultra-High Speed Swept Source Optical Coherence Tomography Angiography Compared to Spectral Domain Optical Coherence Tomography Angiography. In Investigative Ophthalmology & Visual Science. Seattle, WA, USA, US: ARVO: ARVO.

MLA:

Louzada, Ricardo N., et al. "Choroidal Neovascularization Analyzed on Ultra-High Speed Swept Source Optical Coherence Tomography Angiography Compared to Spectral Domain Optical Coherence Tomography Angiography." Proceedings of the ARVO Annual Meeting 2016, Seattle, WA, USA ARVO: ARVO, 2016.

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