Hydrogel matrices based on elastin and alginate for tissue engineering applications

Silva R, Singh R, Sarker B, Papageorgiou DG, Juhasz-Bortuzzo JA, Roether J, Cicha I, Kaschta J, Schubert DW, Chrissafis K, Detsch R, Boccaccini AR (2018)

Publication Status: Published

Publication Type: Journal article

Publication year: 2018



Book Volume: 114

Pages Range: 614-625

DOI: 10.1016/j.ijbiomac.2018.03.091


Hydrogels from natural polymers are widely used in tissue engineering due to their unique properties, especially when regarding the cell environment and their morphological similarity to the extracellular matrix (ECM) of native tissues. In this study, we describe the production and characterization of novel hybrid hydrogels composed of alginate blended with elastin from bovine neck ligament. The properties of elastin as a component of the native ECM were combined with the excellent chemical and mechanical stability as well as biocompatibility of alginate to produce two hybrid hydrogels geometries, namely 2D films obtained using sonication treatment and 3D microcapsules produced by pressure-driven extrusion. The resulting blend hydrogels were submitted to an extensive physico-chemical characterization. Furthermore, the biological compatibility of these materials was assessed using normal human dermal fibroblasts, indicating the suitability of this blend for soft tissue engineering. (C) 2018 Elsevier B.V. All rights reserved.

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Silva, R., Singh, R., Sarker, B., Papageorgiou, D.G., Juhasz-Bortuzzo, J.A., Roether, J.,... Boccaccini, A.R. (2018). Hydrogel matrices based on elastin and alginate for tissue engineering applications. International Journal of Biological Macromolecules, 114, 614-625. https://doi.org/10.1016/j.ijbiomac.2018.03.091


Silva, Raquel, et al. "Hydrogel matrices based on elastin and alginate for tissue engineering applications." International Journal of Biological Macromolecules 114 (2018): 614-625.

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