NOBF4-Functionalized Au-Fe3O4 Nanoheterodimers for Radiation Therapy: Synergy Effect Due to Simultaneous Reactive Oxygen and Nitrogen Species Formation

Klein S, Harreiß C, Menter C, Hümmer J, Distel L, Meyer K, Hock R, Kryschi C (2018)


Publication Status: Published

Publication Type: Journal article

Publication year: 2018

Journal

Publisher: AMER CHEMICAL SOC

Book Volume: 10

Pages Range: 17071-17080

Journal Issue: 20

DOI: 10.1021/acsami.8b03660

Abstract

Snowman-shaped Au-Fe3O4 nanoheterodimers were synthesized by thermal decomposition of iron oleate on presynthesized Au nanoparticles. Subsequently performed ligand exchange with nitrosyl tetrafluoroborate provided water solubility and enabled X-ray-induced NO release. These Au-Fe3O4 nanoheterodimers combine high-Z material with catalytically active Fe3O4 surfaces and, moreover, plasmonic properties with superparamagnetic performance. We could establish synergetic interactions between X-radiation and both the Au and Fe3O4 surfaces, which resulted in the simultaneous production of the nitric oxide radical at the Fe3O4 surface and the superoxide radical at the Au surface. The surface-confined reaction between these radicals generated peroxynitrite. This highly reactive species may cause nitration of mitochondrial proteins and lipid peroxidation and induce DNA strand breaks. Therefore, high concentrations of peroxynitrite are expected to give rise to severe cellular energetic derangements and thereupon entail rapid cell death. As providing a common platform for X-ray-induced formation of the highly superoxide, and peroxynitrite, nitrosyl tetrafluoroborate functionalized Au-Fe3O4 nanosnowmen were shown to exhibit excellent performance as X-ray-enhancing agents in radiation therapy.

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APA:

Klein, S., Harreiß, C., Menter, C., Hümmer, J., Distel, L., Meyer, K.,... Kryschi, C. (2018). NOBF4-Functionalized Au-Fe3O4 Nanoheterodimers for Radiation Therapy: Synergy Effect Due to Simultaneous Reactive Oxygen and Nitrogen Species Formation. ACS Applied Materials and Interfaces, 10(20), 17071-17080. https://doi.org/10.1021/acsami.8b03660

MLA:

Klein, Stefanie, et al. "NOBF4-Functionalized Au-Fe3O4 Nanoheterodimers for Radiation Therapy: Synergy Effect Due to Simultaneous Reactive Oxygen and Nitrogen Species Formation." ACS Applied Materials and Interfaces 10.20 (2018): 17071-17080.

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