Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro

Patin EC, Willcocks S, Orr S, Ward TH, Lang R, Schaible UE (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Innate Immunity SAGE Publications (UK and US)

Book Volume: 22

Pages Range: 181-5

Journal Issue: 3

DOI: 10.1177/1753425916636671

Abstract

The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.

Authors with CRIS profile

Roland Lang Professur für Angeborene Immunität und Pathogenerkennung

Involved external institutions

Cardiff University GB United Kingdom (GB) London School of Hygiene and Tropical Medicine GB United Kingdom (GB)

How to cite

APA:

Patin, E.C., Willcocks, S., Orr, S., Ward, T.H., Lang, R., & Schaible, U.E. (2016). Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro. Innate Immunity, 22(3), 181-5. https://doi.org/10.1177/1753425916636671

MLA:

Patin, Emmanuel C., et al. "Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro." Innate Immunity 22.3 (2016): 181-5.

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