Neutrophils and neutrophil extracellular traps orchestrate initiation and resolution of inflammation

Hahn J, Knopf J, Maueröder C, Kienhoefer D, Leppkes M, Herrmann M (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Clinical and Experimental Rheumatology Clinical and Experimental Rheumatology Sas

Book Volume: 34

Pages Range: 6-8

Journal Issue: 4 Suppl 98

Abstract

Neutrophils, the most abundant leukocytes in the human body, are considered to be the first line of defense in the fight against microorganisms. In this fight neutrophils employ weaponry such as reactive oxygen species produced via the NADPH oxidase complex 2 together with the release of intracellular granules containing antimicrobial agents. The discovery that activated neutrophils release decondensed chromatin as DNase-sensitive neutrophil extracellular traps (NETs) lead to a renewed interest in these leukocytes and the function of NETs in vivo. In this review, we will focus on desirable as well as detrimental features of NETs by the example of gout and pancreatitis. In our models we observed that neutrophils drive the initiation of inflammation and are required for the resolution of inflammation.

Authors with CRIS profile

Jonas Hahn Department of Medicine 3 – Rheumatology and Immunology Jasmin Knopf Department of Medicine 3 – Rheumatology and Immunology Christian Maueröder Department of Medicine 3 – Rheumatology and Immunology Martin Herrmann Department of Medicine 3 – Rheumatology and Immunology

How to cite

APA:

Hahn, J., Knopf, J., Maueröder, C., Kienhoefer, D., Leppkes, M., & Herrmann, M. (2016). Neutrophils and neutrophil extracellular traps orchestrate initiation and resolution of inflammation. Clinical and Experimental Rheumatology, 34(4 Suppl 98), 6-8.

MLA:

Hahn, Jonas, et al. "Neutrophils and neutrophil extracellular traps orchestrate initiation and resolution of inflammation." Clinical and Experimental Rheumatology 34.4 Suppl 98 (2016): 6-8.

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