CD101 inhibits the expansion of colitogenic T cells

Schey R, Dornhoff H, Baier JLC, Purtak M, Opoka R, Koller AK, Atreya R, Rau T, Daniel C, Amann KU, Bogdan C, Mattner J (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Mucosal Immunology Nature Publishing Group: Open Access Hybrid Model Option A

Book Volume: 9

Pages Range: 1205-17

Journal Issue: 5

DOI: 10.1038/mi.2015.139

Abstract

CD101 exerts negative-costimulatory effects in vitro, but its function in vivo remains poorly defined. CD101 is abundantly expressed on lymphoid and myeloid cells in intestinal tissues, but absent from naïve splenic T cells. Here, we assessed the impact of CD101 on the course of inflammatory bowel disease (IBD). Using a T-cell transfer model of chronic colitis, we found that in recipients of naïve T cells from CD101(+/+) donors up to 30% of the recovered lymphocytes expressed CD101, correlating with an increased interleukin (IL)-2-mediated FoxP3 expression. Transfer of CD101(-/-) T cells caused more severe colitis and was associated with an expansion of IL-17-producing T cells and an enhanced expression of IL-2R?/? independently of FoxP3. The co-transfer of naïve and regulatory T cells (Treg) protected most effectively from colitis, when both donor and recipient mice expressed CD101. Although the expression of CD101 on T cells was sufficient for Treg-function and the inhibition of T-cell proliferation, sustained IL-10 production required additional CD101 expression by myeloid cells. Finally, in patients with IBD a reduced CD101 expression on peripheral and intestinal monocytes and CD4(+) T cells correlated with enhanced IL-17 production and disease activity. Thus, CD101 deficiency is a novel marker for progressive colitis and potential target for therapeutic intervention.

Authors with CRIS profile

Regina Schey Professur für Medizinische Mikrobiologie und Infektionsimmunologie Raja Atreya Professur für Translationale Immunforschung bei chronisch entzündlichen Darmerkrankungen (Heisenberg-Professur) Christoph Daniel Department of Nephropathology Kerstin Ute Amann Department of Nephropathology Christian Bogdan Lehrstuhl für Mikrobiologie und Infektionsimmunologie Jochen Mattner Professur für Medizinische Mikrobiologie und Infektionsimmunologie

Involved external institutions

Cincinnati Children's Hospital Medical Center US United States (USA) (US)

How to cite

APA:

Schey, R., Dornhoff, H., Baier, J.L.C., Purtak, M., Opoka, R., Koller, A.K.,... Mattner, J. (2016). CD101 inhibits the expansion of colitogenic T cells. Mucosal Immunology, 9(5), 1205-17. https://doi.org/10.1038/mi.2015.139

MLA:

Schey, Regina, et al. "CD101 inhibits the expansion of colitogenic T cells." Mucosal Immunology 9.5 (2016): 1205-17.

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