CD101 inhibits the expansion of colitogenic T cells

Schey R, Dornhoff H, Baier JLC, Purtak M, Opoka R, Koller AK, Atreya R, Rau T, Daniel C, Amann KU, Bogdan C, Mattner J (2016)


Publication Type: Journal article

Publication year: 2016

Journal

Book Volume: 9

Pages Range: 1205-17

Journal Issue: 5

DOI: 10.1038/mi.2015.139

Abstract

CD101 exerts negative-costimulatory effects in vitro, but its function in vivo remains poorly defined. CD101 is abundantly expressed on lymphoid and myeloid cells in intestinal tissues, but absent from naïve splenic T cells. Here, we assessed the impact of CD101 on the course of inflammatory bowel disease (IBD). Using a T-cell transfer model of chronic colitis, we found that in recipients of naïve T cells from CD101(+/+) donors up to 30% of the recovered lymphocytes expressed CD101, correlating with an increased interleukin (IL)-2-mediated FoxP3 expression. Transfer of CD101(-/-) T cells caused more severe colitis and was associated with an expansion of IL-17-producing T cells and an enhanced expression of IL-2R?/? independently of FoxP3. The co-transfer of naïve and regulatory T cells (Treg) protected most effectively from colitis, when both donor and recipient mice expressed CD101. Although the expression of CD101 on T cells was sufficient for Treg-function and the inhibition of T-cell proliferation, sustained IL-10 production required additional CD101 expression by myeloid cells. Finally, in patients with IBD a reduced CD101 expression on peripheral and intestinal monocytes and CD4(+) T cells correlated with enhanced IL-17 production and disease activity. Thus, CD101 deficiency is a novel marker for progressive colitis and potential target for therapeutic intervention.

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APA:

Schey, R., Dornhoff, H., Baier, J.L.C., Purtak, M., Opoka, R., Koller, A.K.,... Mattner, J. (2016). CD101 inhibits the expansion of colitogenic T cells. Mucosal Immunology, 9(5), 1205-17. https://doi.org/10.1038/mi.2015.139

MLA:

Schey, Regina, et al. "CD101 inhibits the expansion of colitogenic T cells." Mucosal Immunology 9.5 (2016): 1205-17.

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