Coexistence of dilute and densely packed domains of ligand-receptor bonds in membrane adhesion

Schmidt D, Bihr T, Seifert U, Smith AS (2012)

Publication Language: English

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2012

Journal

EPL - Europhysics Letters Institute of Physics: EPL

Publisher: EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY

Book Volume: 99

Article Number: 38003

Journal Issue: 3

URI: http://iopscience.iop.org/article/10.1209/0295-5075/99/38003/meta

DOI: 10.1209/0295-5075/99/38003

Abstract

We analyze the stability of micro-domains of ligand-receptor bonds that mediate the adhesion of biological model membranes. After evaluating the effects of membrane fluctuations on the binding affinity of a single bond, we characterize the organization of bonds within the domains by theoretical means. In a large range of parameters, we find the commonly suggested dense packing to be separated by a free energy barrier from a regime in which bonds are sparsely distributed. If bonds are mobile, a coexistence of the two regimes should emerge, which agrees with recent experimental observations. Copyright (C) EPLA, 2012

Authors with CRIS profile

Ana-Suncana Smith Physics Underlying Life Science (PULS)

Additional Organisation(s)

Exzellenz-Cluster Engineering of Advanced Materials (EAM)

Related research project(s)

None - None

Involved external institutions

Universität Stuttgart DE Germany (DE)

How to cite

APA:

Schmidt, D., Bihr, T., Seifert, U., & Smith, A.-S. (2012). Coexistence of dilute and densely packed domains of ligand-receptor bonds in membrane adhesion. EPL - Europhysics Letters, 99(3). https://doi.org/10.1209/0295-5075/99/38003

MLA:

Schmidt, Daniel, et al. "Coexistence of dilute and densely packed domains of ligand-receptor bonds in membrane adhesion." EPL - Europhysics Letters 99.3 (2012).

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