Optimization of Single Voxel MR Spectroscopy Sequence Parameters and Data Analysis Methods for Thermometry in Deep Hyperthermia Treatments

Hartmann J, Gellermann J, Brandt T, Schmidt M, Pyatykh S, Hesser J, Ott O, Fietkau R, Bert C (2016)

Publication Type: Journal article

Publication year: 2016

Journal

DOI: 10.1177/1533034616656310

Abstract

The difference in the resonance frequency of water and methylene moieties of lipids quantifies in magnetic resonance spectroscopy the absolute temperature using a predefined calibration curve. The purpose of this study was the investigation of peak evaluation methods and the magnetic resonance spectroscopy sequence (point-resolved spectroscopy) parameter optimization that enables thermometry during deep hyperthermia treatments.Different Lorentz peak-fitting methods and a peak finding method using singular value decomposition of a Hankel matrix were compared. Phantom measurements on organic substances (mayonnaise and pork) were performed inside the hyperthermia 1.5-T magnetic resonance imaging system for the parameter optimization study. Parameter settings such as voxel size, echo time, and flip angle were varied and investigated.Usually all peak analyzing methods were applicable. Lorentz peak-fitting method in MATLAB proved to be the most stable regardless of the number of fitted peaks, yet the slowest method. The examinations yielded an optimal parameter combination of 8 cm(3) voxel volume, 55 millisecond echo time, and a 90° excitation pulse flip angle.The Lorentz peak-fitting method in MATLAB was the most reliable peak analyzing method. Measurements in homogeneous and heterogeneous phantoms resulted in optimized parameters for the magnetic resonance spectroscopy sequence for thermometry.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Tübingen Germany (DE) Ruprecht-Karls-Universität Heidelberg Germany (DE)

How to cite

APA:

Hartmann, J., Gellermann, J., Brandt, T., Schmidt, M., Pyatykh, S., Hesser, J.,... Bert, C. (2016). Optimization of Single Voxel MR Spectroscopy Sequence Parameters and Data Analysis Methods for Thermometry in Deep Hyperthermia Treatments. Technology in Cancer Research & Treatment. https://doi.org/10.1177/1533034616656310

MLA:

Hartmann, Josefin, et al. "Optimization of Single Voxel MR Spectroscopy Sequence Parameters and Data Analysis Methods for Thermometry in Deep Hyperthermia Treatments." Technology in Cancer Research & Treatment (2016).

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