Renal denervation in hypertensive patients not on blood pressure lowering drugs

De Jager RL, Sanders MF, Bots ML, Lobo MD, Ewen S, Beeftink MMA, Boehm M, Daemen J, Doerr O, Hering D, Mahfoud F, Nef H, Ott C, Saxena M, Schmieder R, Schlaich MP, Spiering W, Tonino PAL, Verloop WL, Vink EE, Vonken EJ, Voskuil M, Worthley SG, Blankestijn PJ (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Clinical Research in Cardiology Springer Verlag (Germany)

Book Volume: 105

Pages Range: 755-62

Journal Issue: 9

DOI: 10.1007/s00392-016-0984-y

Abstract

Studies on the blood pressure lowering effect of renal denervation (RDN) in resistant hypertensive patients have produced conflicting results. Change in medication usage during the studies may be responsible for this inconsistency. To eliminate the effect of medication usage on blood pressure we focused on unmedicated hypertensive patients who underwent RDN.Our study reports on a cohort of patients, who were not on blood pressure lowering drugs at baseline and during follow-up, from eight tertiary centers. Data of patients were used when they were treated with RDN and had a baseline office systolic blood pressure (SBP) >=140 mmHg and/or 24-h ambulatory SBP >=130 mmHg. Our primary outcome was defined as change in office and 24-h SBP at 12 months after RDN, compared to baseline. Fifty-three patients were included. There were three different reasons for not using blood pressure lowering drugs: (1) documented intolerance or allergic reaction (57 %); (2) temporary cessation of medication for study purposes (28 %); and (3) reluctance to take antihypertensive drugs (15 %). Mean change in 24-h SBP was -5.7 mmHg [95 % confidence interval (CI) -11.0 to -0.4; p = 0.04]. Mean change in office SBP was -13.1 mmHg (95 % CI -20.4 to -5.7; p = 0.001). No changes were observed in other variables, such as eGFR, body-mass-index and urinary sodium excretion.This explorative study in hypertensive patients, who are not on blood pressure lowering drugs, suggests that at least in some patients RDN lowers blood pressure.

Authors with CRIS profile

Christian Ott Medizinische Fakultät Roland Schmieder Professur für Innere Medizin (Nephrologie)

Involved external institutions

University Medical Centre Utrecht (UMC Utrecht) NL Netherlands (NL) University of Adelaide AU Australia (AU) Catharina Hospital / Catharina Ziekenhuis NL Netherlands (NL) University of Western Australia (UWA) AU Australia (AU) Queen Mary, University of London GB United Kingdom (GB) Justus-Liebig-Universität Gießen DE Germany (DE) Universitätsklinikum des Saarlandes (UKS) DE Germany (DE) Erasmus University Medical Center (MC) NL Netherlands (NL)

How to cite

APA:

De Jager, R.L., Sanders, M.F., Bots, M.L., Lobo, M.D., Ewen, S., Beeftink, M.M.A.,... Blankestijn, P.J. (2016). Renal denervation in hypertensive patients not on blood pressure lowering drugs. Clinical Research in Cardiology, 105(9), 755-62. https://doi.org/10.1007/s00392-016-0984-y

MLA:

De Jager, Rosa L., et al. "Renal denervation in hypertensive patients not on blood pressure lowering drugs." Clinical Research in Cardiology 105.9 (2016): 755-62.

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