Structural Characterization of Lecithin-Stabilized Tetracosane Lipid Nanoparticles. Part II: Suspensions

Schmiele M, Busch S, Morhenn H, Schindler T, Schmutzler T, Schweins R, Lindner P, Boesecke P, Westermann M, Steiniger F, Funari SS, Unruh T (2016)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2016

Journal

Journal of Physical Chemistry B American Chemical Society

Publisher: American Chemical Society

Book Volume: 120

Pages Range: 5513-5526

Journal Issue: 24

DOI: 10.1021/acs.jpcb.6b02520

Abstract

Using photon correlation spectroscopy, transmission electron microscopy, microcalorimetry, wide-angle X-ray scattering (WAXS), and small-angle X-ray and neutron scattering (SAXS, SANS), the structure of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC)-stabilized colloidal tetracosane suspensions was studied from the molecular level to the microscopic scale as a function of the temperature. The platelike nanocrystals exhibit for tetracosane an unusual orthorhombic low-temperature crystal structure. The corresponding WAXS pattern can be reproduced with a predicted orthorhombic unit cell (space group Pca2), which usually occurs only for much longer even-numbered n-alkanes. Special emphasis was placed on the structure of the DMPC stabilizer layer covering the nanocrystals. Their structure was investigated by SAXS and SANS, using suspensions with different neutron scattering contrasts. As for the emulsions in Part I, the crystallized nanoparticles are covered by a DMPC monolayer. Their significant smaller thickness of 10.5 å (for the emulsions in Part I: 16 å) could be related to a more tilted orientation of the DMPC molecules to cover the expanded surface of the crystallized nanoparticles.

Authors with CRIS profile

Martin Schmiele Professur für Nanomaterialcharakterisierung (Streumethoden) Torben Schindler Professur für Nanomaterialcharakterisierung (Streumethoden) Tilo Schmutzler Professur für Nanomaterialcharakterisierung (Streumethoden) Tobias Unruh Professur für Nanomaterialcharakterisierung (Streumethoden)

Additional Organisation(s)

Graduiertenkolleg 1896/2 In situ Mikroskopie mit Elektronen, Röntgenstrahlen und Rastersonden Exzellenz-Cluster Engineering of Advanced Materials (EAM) Interdisziplinäres Zentrum, Center for Nanoanalysis and Electron Microscopy (CENEM)

Involved external institutions

European Synchrotron Radiation Facility (ESRF) FR France (FR) Institute Laue-Langevin (ILL) FR France (FR) Universitätsklinikum Jena DE Germany (DE) Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH (HZG) DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Deutsches Elektronen-Synchrotron DESY DE Germany (DE)

How to cite

APA:

Schmiele, M., Busch, S., Morhenn, H., Schindler, T., Schmutzler, T., Schweins, R.,... Unruh, T. (2016). Structural Characterization of Lecithin-Stabilized Tetracosane Lipid Nanoparticles. Part II: Suspensions. Journal of Physical Chemistry B, 120(24), 5513-5526. https://doi.org/10.1021/acs.jpcb.6b02520

MLA:

Schmiele, Martin, et al. "Structural Characterization of Lecithin-Stabilized Tetracosane Lipid Nanoparticles. Part II: Suspensions." Journal of Physical Chemistry B 120.24 (2016): 5513-5526.

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