Negative-feedback regulation of the Wnt pathway by conductin/axin2 involves insensitivity to upstream signalling

Bernkopf D, Hadjihannas M, Behrens J (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Journal of Cell Science Company of Biologists

Book Volume: 128

Pages Range: 33-9

Journal Issue: 1

DOI: 10.1242/jcs.159145

Abstract

Axin and conductin (also known as axin2) are structurally related inhibitors of Wnt/?-catenin signalling that promote degradation of ?-catenin. Whereas axin is constitutively expressed, conductin is a Wnt target gene implicated in Wnt negative-feedback regulation. Here, we show that axin and conductin differ in their functional interaction with the upstream Wnt pathway component Dvl. Conductin shows reduced binding to Dvl2 compared to axin, and degradation of ?-catenin by conductin is only poorly blocked by Dvl2. We propose that insensitivity to Dvl is an important feature of the role of conductin as a negative-feedback regulator of Wnt signalling.

Authors with CRIS profile

Dominic Bernkopf Lehrstuhl für Experimentelle Medizin II (Molekulare Tumorforschung) (EXP2MED) Michel Hadjihannas Lehrstuhl für Experimentelle Medizin II (Molekulare Tumorforschung) (EXP2MED) Jürgen Behrens Lehrstuhl für Experimentelle Medizin II (Molekulare Tumorforschung) (EXP2MED)

How to cite

APA:

Bernkopf, D., Hadjihannas, M., & Behrens, J. (2015). Negative-feedback regulation of the Wnt pathway by conductin/axin2 involves insensitivity to upstream signalling. Journal of Cell Science, 128(1), 33-9. https://doi.org/10.1242/jcs.159145

MLA:

Bernkopf, Dominic, Michel Hadjihannas, and Jürgen Behrens. "Negative-feedback regulation of the Wnt pathway by conductin/axin2 involves insensitivity to upstream signalling." Journal of Cell Science 128.1 (2015): 33-9.

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